Delivering effective amount of drugs across the biological barriers to elicit the desired pharmacological activity is the true focus of the novel drug delivery technologies. Our group allied areas of interest include developing noninvasive technologies for intervention of diseases and sampling of drugs or biomarkers from the tissues.
Transdermal drug delivery has been an interesting and attractive method of administration of drugs via the skin. Our laboratory focuses on development of novel passive and active methods of enhancing the transcutaneous delivery of therapeutic agents for the treatment of regional and systemic diseases. Electrically mediated techniques are being investigated with an objective to improve their drug delivery/targeting efficiency.
Trans-ungual delivery of drugs is highly challenging due to
impermeable nature of nail plate. We are developing techniques for rapid delivery of drugs across the human nail plate.Trans-ungual iontophoresis and electropulsation have shown promising results in this direction.
Dermatokinetics of drugs determines the activity/toxicity of drugs used in the treatment of skin diseases. Often drug levels in the dermal extracellular fluid also serves as a surrogate to the drug levels in some of the peripheral tissues. Developing noninvasive sampling of drugs and biomarkers from the skin and study of dermatokinetics of drugs is one of our
Targeting drugs to brain via intranasal administration is one of
the on going research projects. Novel approaches to enhance the bioavailability of drugs and macromolecules to brain are being investigated currently.