Kristine L. Willett

University of Mississippi

Department of BioMolecular Sciences

Divisions of Environmental Toxicology and Pharmacology

305 Faser Hall, Box1848

University, MS 38677

(662) 915-6691

kwillett@olemiss.edu

 

 

EDUCATION

1993 – 1997   Texas A&M University

                        Ph.D. in Toxicology, Reagents Fellow

Dr. Stephen Safe, Advisor.

Thesis: Development of bioassays for polynuclear aromatic hydrocarbon contamination in the marine environment.

 

1989 – 1993   University of North Carolina, Chapel Hill, NC

                        B.A. with Honors and Distinction in Chemistry

 

 

EMPLOYMENT

2017 -              Chair, Department of BioMolecular Sciences, University of Mississippi

2013 -              Professor of Pharmacology and Environmental Toxicology, BioMolecular Sciences, University of Mississippi

2006 - 2013     Associate Professor of Pharmacology, Environmental Toxicology Research Program, University of Mississippi

2000 - 2006     Assistant Professor of Pharmacology, Environmental Toxicology Research Program, University of Mississippi

 1998 – 2000   RJR Leon Golberg Fellowship in Toxicology, Duke University. Dr. Richard DiGiulio, Advisor.

1997 - 1998    Dreyfus Postdoctoral Fellow in Environmental Chemistry, Indiana University. Dr. Ronald Hites, Advisor.

1993                Research Assistant, Geochemical and Environmental Research Group, Texas A&M University, Department of Geosciences.

1991 – 1992    Summer Intern, Chemical Industries Institute of Toxicology, Experimental Pathology and Toxicology Division, Teratology Section and Biochemical Toxicology Section.

 1990              Professional Intern, Oak Ridge National Laboratory, Environmental Sciences Division, Biogeochemistry Section.

1987 - 1989     Summer Research Assistant, Ohio Agricultural Research and Developmental Center, Animal Science Department, Rumen Microbiology Laboratory and Laboratory for Pesticide Control and Application Technologies.

 

 

EDITORIAL BOARDS

           

            Toxicological Sciences- Associate Editor

            Aquatic Toxicology

 

HONORS

           

            UM School of Pharmacy, Faculty Service Award 2013 - 2014

            UM School of Pharmacy, Distinguished Teaching Scholar, 2014 – 2017

            UM Sally McDonald Barksdale Honors College Faculty Member of the Year 2016

 

PROPOSAL PANELS REVIEW

 

NIEHS Environmental Health Sciences Standing Review Panel Fall 2011 - 2015

NIEHS Superfund panel 2008, 2010, 2016

NIEHS Deepwater Horizon Consortia panel 2011

NIH XNDA, SBIR, SIEE panels

EPA Star panel 2005

NSF Ad hoc reviewer

Sea Grant review panels

MS Water Resources Research Institute (Advisory Board Member/Reviewer) 2014 -

 

PROFESSIONAL SOCIETIES

 

Society of Toxicology (SOT)

Molecular and Systems Biology Specialty Section

South Central Regional Chapter

Society of Environmental Toxicology and Chemistry (SETAC)

            MidSouth Regional Chapter

American Association of Colleges of Pharmacy

Rho Chi

 

SOT LEADERSHIP

 

South Central Chapter of SOT 

Member since 2000 and have served as Councilor, Secretary/Treasurer (2004-2006), VP elect – Past-President (2006-2010) and organized and hosted regional meeting at Ole Miss in 2007 and 2014.

 

Molecular and Systems Biology Specialty Section

Member since 1990s. Secretary/Treasurer (2007 – 2011), Junior – Senior Councilor (2011 – 2013), Presidential chain (2013-2017), currently Past-President

 

Undergraduate Education Resources Task Force

Member April 2010 - 2013

Undergraduate Education Subcommittee of the Education Committee

Member since 2013. Currently Chair

            2014 Archive Vision and Change Scholars Program – NSF supported; 8 Week-Online course.

 

Deepwater Horizon Response

Asked by SOT president to be part of a team of scientists to prepare the SOT Issue Statement related to the Deepwater Horizon Oil Spill.  www.toxicology.org/pm/Deepwater_oil_spill.pdf - 2011-10-21 and update statement 2016.

 

SETAC LEADERSHIP

 

SETAC North America Board of Directors (2015 – 2018)

            Board Liaison to North American Student Advisory Council

            Board Liaison to Student Activities Committee

 

Mid-South SETAC Presidential Chain (2016-2017), currently President

            Will host regional chapter meeting in Oxford in May, 2017

 

 

GRANTS

 

Willett,K.L., and R.T. Di Giulio. Co-Principle Investigators, July 2000 – Jan. 2002. “Characterization of CYP1B1 gene activation in fish for use as a possible marker of cancer resistance.” North Carolina Biotechnology Center. $53,107

 

Willett,K.L. Principle Investigator, March 2001 – May 2005 “Screening of environmental contaminants detected in Mississippi sediments as inducers and/or inhibitors of CYP1B1 expression in channel catfish.” State Water Resources Research Program. $129,150

 

Willett,K.L., Principle Investigator, 2001 “CYP1B1-Dependent estrogen metabolism and oxidative stress in two related species of catfish.” University of Mississippi Faculty Research Program. $5000

 

Slattery,M., Principle Investigator, November 2000 - April 2003 “Environmental Toxicology Congressional Initiative Environmental Signals and Sensors” CDC. Participant in Cluster Three: Chemicals, genes and development: genetic factors in susceptibility to environmental agents, specifically characterizing the role of CYP1B1 as a marker of cancer susceptibility. $97,828

 

Willett,K.L. and C.M. Foran, Co-Investigators, August 2001 - August 2002.“Characterization of bioassays and chemical contaminants in croaker, oyster and sediments collected at two sites in the Mobile Bay National Estuary.” Mobile Bay National Estuary Program. $5000

 

Willett,K.L. Principle Investigator, Dec. 2002 - Nov. 2003. “Characterization of flavonoids’ ability to decrease CYP1B1 activity.” American Association of Colleges of Pharmacy New Investigators Program. $10,000

 

Willett,K.L., Principle Investigator, Nov. 2003 – April 2004. “Flavonoid-mediated gene expression in human cancer cells.” Mississippi Functional Genomics Network SGO. $30,000

 

Slattery,M., Willett, K.L. Co-PIs Nov. 2002 – October 2010. “Biosensors” NOAA-National Institute of Undersea Science and Technology. $191,675

 

Willett,K.L. University of Mississippi Associates’ and Partners’ Program. Criterion Precast Gel Electrophoresis System and Blotter 12/10/03. $942

 

Willett,K.L., Principle Investigator, NIH R01 + ARRA supplement. July 2004 – August 2010. Roles of CYP1& CYP19 in Fundulus Steroid & PAH Metabolism. NIEHS. $1,241,361 + $86,219 supplement.

 

Dasmahapatra, A., Principle Investigator, Willett, K.L., Co-PI. NIH R03. July 2007 – June 2009. Ethanol action in Japanese medaka: Alteration in specific gene methylation. NIAAA. $140,200

 

Willett, K.L, and Slattery, M. Co-PIs. Feb. 2009 – Aug 2009. YES Assay analyses of Cruise Ship Samples. SGS Environmental Services and Florida Spectrum Environmental Services. $6,750

 

Willett, K.L. and J. Rimoldi Co-PIs, Oct. 2009 – October 2011.  “Seagrass Proteomics: Profiling and Surveillance in the Gulf of Mexico” NOAA-National Institute of Undersea Science and Technology. $100,000

 

Slattery, M., Principle Investigator, Gochfeld, D., Willett, K., Rimoldi, J., Boettcher, A., Co-PIs. Sept 2010 – Mar 2011. “Impacts of oil contamination to seagrass beds: Proteomic response” Northern Gulf Institute. $96,629

 

Willett, K.L., Principle Investigator, NIH R03. Apr 2010 – Mar 2012. “BaP-mediated reproductive and developmental toxicity” NIEHS. $138,916

 

Willett, K.L., Principle Investigator, Feb. 2009 – Sept. 2014. “Distribution, bioaccumulation and toxicity of nanosilver particles in medaka (Oryzias latipes)” US Army Engineering Research and Development Center. $527,919

 

Willett, K.L., Principle Investigator, NIH R21, Aug. 2011 – July. 2014. “Development of a fish model for epigenetic & multigenerational contaminant effects” NIEHS $384,650

 

Willett, K.L. Principle Investigator on Pilot Project, NIH P20 Pilot Project. Jan 2016 – Sept 2017. “Identifying novel cannabinoid analogues for the treatment of Dravet Syndrome” NIGMS $72,000

 

Willett, K.L., Principle Investigator, Intergovernmental Personnel Act Agreement with US Army Engineer ERDC. $40,100. 8/12/15 – 9/13/18.

 

Otts, S.S. Principle Investigator, Willett, K.L. and Green, J. Co-PIs. June 2016 – June 2017. “Reducing lead levels in Mississippi drinking water: Informing the policy debate through risk assessment and legal research” UM ORSP Investment Grant $7,000

 

Brooks, T. and Willett, K.L. Co-Principle Investigators. June 2016 – June 2017. “Developing an in vitro and in vivo model to screen chemotherapeutic compounds for the treatment of breast cancer” UM ORSP Investment Grant $8,156

 

Willett, K.L. Principle Investigator, Otts, SS and Green, J. Co-PIs. March 2017 – February 2018. “Assessing the effectiveness of community-based research strategies to analyze risk of lead contamination in public water supplies in the Mississippi Delta” Mississippi Water Resources Research Institute (WRRI) $30,185

 

 

 

PUBLICATIONS

 

The entire list of Dr. Willett’s publications can be found at: http://www.ncbi.nlm.nih.gov/sites/myncbi/kristine.willett.1/bibliography/48034842/public/?sort=date&direction=ascending

1)      Willett, K.L., Loerch, S.C., and Willett, L.B. 1989. Effects of halogenated hydrocarbons on rumen microorganisms. J.Veterinary Diagnostic Investigations.1:120-123.

2)      Willett, K.L., Turner, R.R and Beauchamp, J.J. 1992. Effect of chemical form of mercury on the performance of dosed soils in standard leaching protocols: EP and TCLP. Hazardous Waste and Hazardous Materials. 9:275-288.

3)      Fister, T.F., Strossman, G.S., Willett, K.L., Odom, R.W. and Linton, R.W. 1995. In situ analysis of organic monolayers and their reactivity on single micrometer-sized particles by time-of-flight secondary ion mass spectrometry. International J. of Mass Spectrometry & Ion Processes.143:87-111.

4)      Willett, K., Steinberg, M., Thomsen, J., Narasimhan, T.R., Safe, S., McDonald, S., Beatty, K. and Kennicutt, M.C. 1995. Exposure of killifish to benzo[a]pyrene: comparative metabolism, DNA adduct formation and aryl hydrocarbon (Ah) receptor agonist activities. Comparative Biochemistry and Physiology. 112B:93-103.

5)      Bowes, R.C., Parrish, A.R., Steinberg, M.A., Willett, K.L., Zhao,W., Savas, U., Jefcoat, C.R., Safe, S.H. and Ramos, K.S. 1996. Atypical cytochrome P-450 induction profiles in glomerular mesangial cells at the mRNA and enzyme level. Biochemical Pharmacology. 52:587-595.

6)      McDonald, S., Willett, K., Thomsen, J., Narasimhan, T.R., Connor, K., Beatty, K., Erickson, C., and Safe, S. 1996. Sublethal detoxification responses to contaminant exposure associated with offshore production platforms. Canadian J. Fisheries Aquatic Sciences. 53:2606-2617.

7)      Hoivik, D., Wilson, C., Wang, W., Willett, K., Barhoumi, R., Burghardt, R. and Safe, S.1997. Studies on the relationship between estrogen receptor content, glutathione S-transferase p expression and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells. Archives of Biochemistry and Biophysics. 348:174-182.

8)      Fiedler,H., Cooper, K., Bergek,S., Hjelt, M., Rappe, C., Bonner, M., Howell, F., Willett, K. and Safe, S. 1998. PCDD, PCDF, and PCB in farm-raised catfish from Southeast United States. Chemosphere.37:1645-1656.

9)      Hoivik,D., Willett, K., Wilson, C. and Safe, S. 1997. Estrogen does not modulate 2,3,7,8-tetrachlorodibenzo-p-dioxin mediated effects in MCF-7 and Hepa 1c1c7cells. Journal of Biological Chemistry. 272:30270-30274.

10)   Willett,K.L., Gardinali, P., Sericano, J., Wade, T. and Safe, S.H. 1997.Characterization of the H4IIE rat hepatoma cell bioassay for the evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs). Archives of Environmental Contamination and Toxicology. 32:442-448.

11)   Willett,K.L., McDonald, S.J., Steinberg, M.A., Beatty, K.B., Kennicutt, M.C. and Safe,S.H. 1997. Biomarker sensitivity for polynuclear aromatic hydrocarbon contamination in two marine fish species collected in Galveston Bay, Texas. Environmental Toxicology and Chemistry. 16:1472-1479.

12)   Willett,K.L., Randerath, K., Zhou, G-D. and Safe, S.H. 1998. Inhibition of CYP1A1activities by the PAH fluoranthene. Biochemical Pharmacology. 55:831-839.

13)   Willett,K.L., Ulrich, E.M. and Hites, R.A. 1998. Differential toxicity and environmental fates of hexachlorocyclohexane isomers. Environmental Science and Technology. 32:2197-2207.

14)   Willett,K.L., Wilson, C., Thomsen, J. and Porter, W. 1999. Evidence for and against the presence of polynuclear aromatic hydrocarbon and 2,3,7,8-tetrachloro-p-dioxin binding proteins in marine mussels. Aquatic Toxicology. 48:51-64.

15)   Willett,K.L., and Hites, R.A. 2000. Chemical actinometry: Using o-nitrobenzaldehyde to measure lamp intensity in photochemical experiments. Journal of Chemical Education. 77:900-902.

16)   Willett,K.L., Gardinali, P.R., Lienesch, L.A. and Di Giulio, R.T. 2000. Comparative metabolism and excretion of benzo(a)pyrene in two species of Ictalurid catfish. Toxicological Sciences. 58:68-76.

17)   Ulrich,E.M., Willett, K.L., Caperell-Grant, A., Bigsby, R.M. and Hites, R.A. 2001.Understanding enantioselective processes: A laboratory rat model for a-hexachlorocyclohexane (a-HCH) accumulation. Environmental Science and Technology. 35:1604-1609.

18)   Willett,K.L., Lienesch, L.A. and Di Giulio, R.T. 2001. No detectable DNA excision repair in UV-exposed hepatocytes from two species catfish. Comparative Biochemistry and Physiology. 128C:349-358.

19)   Willett,K.L., Wassenberg, D., Lienesch, L.A., Reichert, W. and Di Giulio, R.T. 2001. In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Toxicology and Applied Pharmacology.177:264-271.

20)   Zhang,L., Khan, I.A., Willett, K.L., Foran, C.M. 2003. In vivo effects of black cohosh and genistein on estrogenic activity and lipid peroxidation in Japanese medaka (Oryzias latipes). Journal of Herbal Pharmacotherapy. 3(3):33-50.

21)   Contractor,R., Foran, C.M., Li, S., and Willett, K.L. 2004. Evidence of sex and tissue specific promoter methylation and the potential for ethinylestradiol-induced changes in Japanese medaka (Oryzias latipes) estrogen receptor and aromatase genes. Journal of Toxicology and Environmental Health 67A:1-22.

22)   Annavarapu,S., Foran, C.M., Gardinali, P., Metzger, C., and Willett, K.L. 2004. Comparison of two sites in Mobile Bay using in vivo biomarkers in largemouth bass, sediment bioassays, and sediment contaminant analysis. Archives of Environmental Contamination and Toxicology. 46:502-510.

23)   Butala,H., Metzger, C., Rimoldi, J., and Willett, K.L., 2004. Microsomal estrogen metabolism in channel catfish. Marine Environmental Research. 58:489-494.

24)   Willett,K.L. and Bouldin, A.S., 2004. Development and assessment of an online elective toxicology course. American Journal of Pharmaceutical Education.68 (#57):1-9.

25)   Willett,K.L., Roth, R.A., and Walker, L. 2004. Workshop overview: Hepatotoxicity assessment for botanical dietary supplements. Toxicological Sciences. 79:4-9.

26)   Tabanca,N., Khan, S.I., Bedir, E., Annavarapu, S., Willett, K.L., Khan, I.A., Kirimer,N., and Baser, K.H.C. 2004. Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, Evaluated using a recombinant yeast screen. PlantaMedica. 70:728-735.

27)   Chaudhary,A.M. and Willett, K.L. 2006. Inhibition of human cytochrome CYP1 enzymes by flavonoids of St. John’s wort. Toxicology. 217:194-205.

28)   Patel,M.R., Scheffler, B.E., and Willett, K.L. 2006. Effects of benzo(a)pyrene exposure on killifish (Fundulus heteroclitus) aromatase activities and mRNA.  Aquatic Toxicology. 77:267-278.

29)   Willett, K.L., Ganesan, S., Patel, M., Metzger, C.M., Quiniou, S., Waldbieser, G., Scheffler, B. 2006. In vivo and in vitro CYP1B mRNA expression in channel catfish. Marine Environmental Research. 62: S332-S336.

30)   Zhu, N., Lightsey, D., Foroozesh, M., Alworth, W., Chaudhary, A., Willett, K.L., and Stevens, C.L.K. 2006. Naphthoflavone propargyl ether inhibitors of cytochrome P450. Journal of Chemical Crystallography. Journal of Chemical Crystallography. 36:289-296.

31)   Rao, K.V., Donia, MS., Yousaf, M., Reddy, M.K., Martin-Aparicio, E., Garcia-Palomero, E., Alonso, D., Martinez, A., Medina, M., Franzblau, S.G.,  Tekwani, B.L., Khan, S.I., Wahyuono, S., Willett, K.L., and Hamann, M.T., 2006. New manzamine B, E- and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic and alzheimer’s diseases. Journal of Natural Products. 69:1034-1040.

32)   Wang, L., Scheffler, B.E. and Willett, K.L. 2006. CYP1C1 messenger RNA expression is inducible by benzo(a)pyrene in Fundulus heteroclitus embryos and adults. Toxicological Sciences. 93:331-340.

33)   Chaudhary, A., Pechan, T., and Willett, K.L. 2007. Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22 Rv1 and PrEC prostate cell lines. Toxicology and Applied Pharmacology. 220:197-210.

34)   Dong, W., and Willett, K.L. 2008. Local expression of CYP19A1 and CYP19A2 in developing and adult killifish (Fundulus heteroclitus). General and Comparative Endocrinology. 155: 307-317.

35)   Zhu, S., Li, L., Thorton, C., Carvalho, P., Avery, B.A., and Willett, K.L. 2008. Simultaneous determination of benzo[a]pyrene and eight of its metabolites in Fundulus heteroclitus bile using ultra performance liquid chromatography with mass spectrometry. Journal of Chromatography B. 863:141-149.

36)   Dong, W., Wang, L., Thornton, C., Scheffler, B.E., and Willett, K.L., 2008. Benzo(a)pyrene decreases brain and ovarian aromatase mRNA expression. Aquatic Toxicology. 88: 289-300.

37)   Wills, L.P., Zhu, S., Willett, K.L., and Di Giulio, R.T. 2009. Effect of CYP1A inhibition on the biotransformation of benzo(a)pyrene in two populations of Fundulus heteroclitus with different exposure histories. Aquatic Toxicology. 92:195-201.

38)   Hu, Y, Willett, K.L., Khan, I.A., Scheffler, B.E., and Dasmahapatra, A.K. 2009. Ethanol disrupts chondrification of the neurocranial cartilages in medaka embryos without affecting aldehyde dehydrogenase 1A2 (Aldh1A2) promoter methylation. Comparative Biochemistry and Physiology Part C. 150(4):495-502.

39)   Kasimsetty, S.G., Bialonska, D., Reddy, M.K., Thornton, C., Willett, K.L., and Ferreira, D. 2009. Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. Journal of Agricultural and Food Chemistry. 57(22):10636-10644.

40)   Singh, S.P., Azua, A., Chaudhary, A., Khan, S., Willett, K.L., and Gardinali, P. 2010. Occurrence and distribution of steroids, hormones and selected pharmaceuticals in South Florida coastal environments. Ecotoxicology. 19:338-350.

41)   Fang, X., Dong, W., Thornton, C., Scheffler, B., and Willett, K.L. 2010. Benzo(a)pyrene-induced glycine N-methyltransferase messenger RNA expression in Fundulus heteroclitus embryos. Marine Environmental Research. 69: S74-76.

42)   Weston, J., Warren, C., Chaudhary, A., Emerson, B., Argote, K., Khan, S., and Willett, K.L.  2010. Use of bioassays and sediment PAH concentrations to predict toxicity at coastal Hurricane Katrina impacted sites.  Environmental Toxicology and Chemistry. 29(7):1409-1418.

43)   Scornaienchi, M.L., Thornton, C., Willett, K.L., and Wilson, J.Y. 2010. Cytochrome P450 mediated 17b-estradiol metabolism in zebrafish (Danio rerio) using a heterologous expression system. Journal of Endocrinology. 206: 317-325.

44)   Wang, L., Camus, A., Thornton, C., and Willett, K.L. 2010. Role of CYP1C1 and CYP1A in PAH-induced carcinogenesis in a fish model: Fundulus heteroclitus. Aquatic Toxicology. 99: 439-447.

45)   Fang, X., Dong, W., Thornton, C., and Willett, K.L. 2010. Benzo[a]pyrene increases glycine N-methyltransferase mRNA expression but decreases enzyme activity in Fundulus heteroclitus embryos. Aquatic Toxicology 98:130-138.

46)   Scorniaenchi, M.L., Thornton, C., Willett, K.L., and Wilson, J.Y. 2010. Functional differences in the cytochrome P450 1 family enzymes from zebrafish (Danio rerio) using heterologously expressed proteins. Archives of Biochemistry and Biophysics. 502:17-22.

47)   Wills, L.P., Jung, D., Koehrn, K., Zhu, S., Willett, K.L., Hinton, D.E. and Di Giulio, R.T. 2010. Comparative chronic liver toxicity of benzo[a]pyrene in two populations of the Atlantic killifish (Fundulus heteroclitus) with different exposure histories. Environmental Health Perspectives. 118: 1376-1381.

48)   Duzgoren-Aydin, N.S., Avula, B., Willett, K.L. and Khan, I.A. 2011. Determination of solid-bound trace element concentrations using collision/reaction cell inductively coupled plasma-mass spectrometry. Environmental Monitoring and Assessment. 172: 51-66.

49)   Warren, C., Duzgoren-Aydin, N.S., Weston, J., and Willett, K.L. 2012. Trace element concentration in surface estuarine and marine sediments along the Mississippi gulf coast following Hurricane Katrina. Environmental Monitoring and Assessment. 184: 1107 – 1119.

50)    Master, Z., Chaudhary, A., Sutter, T.R., and Willett, K.L. 2012. Effects of flavonoids on CYP1 expression in RL95-2 endometrial carcinoma cells. Food Chemistry. 133: 912-922.

51)    Slattery, M., Ankisetty, S., Corrales, J., Marsh-Hunkin, K.E., Gochfeld, D.J., Willett, K.L., and Rimoldi, J.M., 2012. Marine Proteomics: A critical assessment of an emerging technology. Journal of Natural Products. 75: 1833-1877.

52)    Karami, A., Syed, M.A., Christianus, A., Willett, K.L., Mazzeo, J.R., Courtenay, S.C., 2012. Fluorescent aromatic compound (FAC) recovery from fish bile by acetone. Journal of Hazardous Materials. 223-224:84-93.

53)    Carmichael, R.H., Jones, A.L, Patterson, H.K., Walton,W.C., Pérez-Huerta, A.,  Overton, E.B.,  Dailey, M., and Willett,K.L., 2012. Assimilation of oil-derived elements by oysters due to the Deepwater Horizon oil spill. Environmental Science and Technology. 46, 12787-12795.

54)    Fang, X., Thornton, C., Scheffler, B.E., and Willett, K.L., 2013. Benzo[a]pyrene decreases global and gene specific DNA methylation during zebrafish development. Environmental Toxicology and Pharmacology. 36, 40-50.

55)    Fang, X., Corrales, J., Thornton, C., Scheffler, B.E., and Willett, K.L., 2013. Global and gene specific DNA methylation changes during zebrafish development. Comparative Biochemistry and Physiology, Part B. 166, 99-108.

56)    Corrales, J., Fang, X., Thornton, C., Mei, W., Barbazuk, W.B., Duke, M., Scheffler, B.E. and Willett, K.L., 2014. Effects on specific promoter DNA methylation in zebrafish embryos and larvae following benzo[a]pyrene exposure. Comparative Biochemistry and Physiology, Part C. 163, 37-46.

57)    Corrales, J., Thornton, C., White, M., and Willett, K.L., 2014. Multigenerational effects of benzo[a]pyrene exposure on survival and developmental deformities in zebrafish larvae. Aquatic Toxicology. 148, 16-26.

58)    Booc, F., Thornton, C., Lister, A., MacLatchy, D., Willett, K.L., 2014. Benzo[a]pyrene effects on reproductive endpoints in Fundulus heteroclitus. Toxicological Sciences. 140, 73-82.

59)    Hawkins, A.D., Bednar, A.J., Cizdziel, J.V., Bu, K., Steevens, J.A., and Willett, K.L., 2014. Identification of silver nanoparticles in Pimephales promelas gastrointestinal tract and gill tissues using flow field flow fractionation ICP-MS. RSC Advances. 4, 41277-41280.

60)    Hawkins, A.D., Thornton, C., Steevens, J.A., and Willett, K.L., 2014. Alteration in Pimephales promelas mucus production after exposure to nanosilver or silver nitrate. Environmental Toxicology and Chemistry.33, 2869-2872.

61)    Hawkins, A.D., Thornton, C., Kennedy, A., Bu, K., Cizdziel, J., Jones, B., Willett, K.L., 2015. Gill histopathologies following exposure to nanosilver or silver nitrate. Journal of Toxicology and Environmental Health, Part A. 78,301-315. 

62)    Garcia-Reyero, N., Thornton, C., Hawkins, A.D., Escalon, L., Kennedy, A. J., Steevens, J.A., Willett, K.L., 2015. Unique particle effects in fathead minnow gill gene expression and mucus production following exposure to nanosilver and silver nitrate. Environmental Nanotechnology, Monitoring and Management. 4: 1-9.

63)    Fang X, Corrales J, Thornton C, Clerk T, Scheffler BE, and Willett KL., 2015. Transcriptomic changes in zebrafish embryos and larvae following benzo[a]pyrene exposure. Toxicological Sciences.  146(2):395-411.

64)    Wolff S, Brown G, Chen J, Meals K, Thornton C, Brewer S, Cizdziel JV, Willett KL. 2016. Mercury concentrations in fish from three major lakes in north Mississippi: Spatial and temporal differences and human health risk assessment. J Toxicol Environ Health A. 79(20):894-904.

65)    Alharthy, KM., Albaqami, FF., Thornton, C., Corrales, J., and Willett, KL., 2016. Mechanistic evaluation of benzo[a]pyrene’s developmental toxicities mediated by reduced Cyp19a1b activity. Toxicological Sciences Sep 14. pii: kfw182. [Epub ahead of print]

 

 

BOOK CHAPTERS

 

1)       Marsh, K.E., Willett, K.L., Foran, C.M. and Brooks, B.W. 2003. Aquatic Resources and Human Health. Chapter 3. In: A Web of Connections: Achieving Sustainable Freshwater Systems. Island Press. Eds: Holland, MM., Blood, E. and Shaffer, L.R. pp 65-83.

2)       Schlenk, D., Celander, M., Gallagher, E.P., George, S., James, M., Kullman, S.W., van den Hurk, P., Willett, K.L. 2008. Biotransformation in Fishes - Chapter 4. In: The Toxicology of Fishes. CRC Press. Eds: R.T. DiGiulio and D.E. Hinton. pp 153-234

3)       Willett, K.L. and Foran, C.M. Ecological and Health Risks at Low Doses. IN Encyclopedia of Sustainability Science and Technology, Springer. Editor-in-chief: Meyers, Robert A. 1st Edition., 2012, 10500 p. 2500 illus. in color. In 12 volumes, not available separately $8100. Hardcover, ISBN 978-0-387-89469-0

4)       Willett, K.L. Considering Epigenetics in Adverse Outcome Pathways. Chapter 6. IN Systems Biology Approaches for Advancing Adverse Outcome Pathways for Risk Assessment. Springer. Eds: N. Garcia-Reyero and C. Murphy. In Press.

 

 

MANUSCRIPT REVIEW

 

Ad hoc reviewer for:

Brain Research, Chemosphere, Comparative Biochemistry and Physiology, Environmental Health Perspectives, Environmental Protection, Environmental Science and Technology, Environmental Toxicology and Chemistry, Environmental Toxicology and Pharmacology, Journal of Biomolecular Screening, J. Chromatography A, Journal of Natural Products, Int. J. Environmental Research and Public Health, Marine Environmental Research, Phytotherapy Research, Planta Medica, Toxicology and Applied Pharmacology, Toxicological Letters

 

 

SCIENTIFIC MEETINGS TYPICALLY ATTENDED

 

Society of Toxicology, Society for Environmental Toxicology and Chemistry, Aquatic Animal Models for Human Disease, Pollutant Responses in Marine Organisms (list of all presentations available on request).

 

 

TEACHING EXPERIENCE

 

University of Mississippi (2000 – 2016)

 

PHCL381:Introduction to Toxicology, Undergraduate Pharmacy and Forensic Chemistry students. 3 credits. Traditional and Online Format. (10 semesters)

PHCL675:Principles of Pharmacology and Toxicology, Graduate Pharmacology students. 4 credits. (9 semesters)

PHCL 347/547: Environmental Toxicology, Undergraduate Pharmacy and Graduate Environmental Toxicology students. 2 credits. (7 semesters)

MEDC317:Pharmacogenetics and Pharmacoimmunology. Co-instructor, taugh 1/3rdof course. P3 Professional Pharmacy students. 3 credits. (2 semesters)

HON 101 and 102: Freshman Seminar, Undergraduate Honors students. 6 credits. (6 semesters each)

PHCL651:Directed Studies in Pharmacology and Toxicology, Graduate Pharmacology students. 1-2 credit. 

PHCL541:Problems in Pharmacology, Graduate Pharmacology students. 2 credits.  

Guest Lectures in PHCL676: Principles of Pharmacology and Toxicology II, GE460:Waste Management, CHEM105: General Chemistry

 

Duke University

 

ENV212:Environmental Toxicology, Instructor of Record. Masters and PhD students in Nicholas School of the Environment. Fall 1999

 

GRADUATE STUDENT COMMITTEES

 

M.S. Committees and Advisees

 

1)    Rooha Contractor – Thesis Co-Advisor (Defense 12/02) Title: Analysis of estrogen receptor and aromatase genes in Japanese medaka: Characterization of promoter methylation.

2)    Luling Zhang – Thesis Co-Advisor (Defense 12/02) Title: Biological activity of natural product components in Japanese medaka (Oryzias latipes): determining estrogenicity and antioxidative potential.

3)    Srinivas Annavarapu – Thesis Advisor (Defense 07/24/03) Title: Use of bioassays to determine receptor-mediated induction of cytochrome P4501A and estrogenic activity in sediment and natural product samples.

4)    Monali Master Patel – Thesis Advisor (Defense 11/21/03) Title: Effects of polycyclic aromatic hydrocarbons on CYP19 and CYP1B expression in teleosts.

5)    Harshala Butala - Thesis Committee (Dr.Ajit Sadana, advisor; Defense 07/25/03). Department of Engineering. Title: A fractal analysis of estrogen estrogen-receptor interactions and estrogen metabolism in two related species of catfish.

6)    Rebecca Rummer - Thesis Committee (Biology student at West Virginia University; Dr. Foran, advisor. Defense 3/29/04)

7)    Zankhana Master - Thesis Advisor (Defense 12/02/04) Title: Effects of flavonoids on CYP1 expression in RL95-2 endometrial carcinoma cells.

8)    Ranjita Kokje - Thesis Committee (Dr. Robert Speth, advisor, Defense 11/06)

9)    Surinder Kaur - Thesis Committee (Dr. Robert Speth, advisor, Defense 04/25/06)

10) Xueqing Wang - Thesis Committee (Dr. Asok Dasmahapatra, advisor, Defense 04/27/06)

11) Jaijia Wang - Thesis Committee (Dr. Matsumoto, advisor, Defense 10/25/07)

12) Crystal Warren–Thesis Advisor (Defense 07/22/09) Environmental Toxicology Graduate Program. Title: Monitoring Effects of Hurricane Katrina to the Mississippi Gulf Coast.

13) Yuhui Hu–Thesis Committee (Dr. Asok Dasmahapatra, advisor, Defense 07/15/09) Environmental Toxicology Graduate Program.

14) Felicia Rabey – Thesis Committee (Dr. Speth, advisor, Defense 09/10/09).

15) Lindsay Krentz O’Donahue – Thesis Committee (Dr. Marc Slattery, advisor, Defense 03/30/10) Environmental Toxicology Graduate Program.

16) Suzanne Seale – Thesis Committee Member (Dr. Abir El-alfy, advisor, Defense 06/10/10). Environmental Toxicology Graduate Program.

17) Meghan Dailey- Thesis Advisor. (Defense 06/22/12). Environmental Toxicology Graduate Program. Title: Temporal and Spatial Assessment of PAHs in Water, Sediment, and Oysters as a result of the Deepwater Horizon Oil Spill.

18) Frank Booc – Thesis Advisor. (Defense 07/22/13). Environmental Toxicology Graduate Program. Topic of study: Reproductive and developmental consequences of benzo[a]pyrene exposure.

Ph.D. Committees and Advisees

 

1)    Duane Huggett - Dissertation Committee (Dr. Waters, advisor, Defense 06/29/01) Department of Pharmacology.

2)    Anand Ramakrishnan- Dissertation Committee (Dr. Ajit Sadana, advisor; Defense 07/22/02) Department of Engineering.

3)    Kenosha Hobson - Dissertation Committee (Dr. Petigo, advisor; Defense 09/18/03) Department of Chemistry.

4)    Francis Tukov – Dissertation Committee (Dr. Matthews, advisor; Defense 11/20/03) Department of Pharmacology.

5)    Amit Chaudhary – Chair Dissertation Committee. (Defense 12/06). Department of Pharmacology. Title: Mechanistic analysis of cancer chemopreventative flavonoids and benzo[a]pyrene in prostate cancer cells.

6)    Shiqian Zhu – Chair Dissertation Committee. (Defense 11/29/07). Department of Pharmacology. Title: The roles of cytochrome P450s in the toxicity of polycyclic aromatic hydrocarbons (PAHs).

7)    Erick Bourassa – Dissertation Committee (Dr. Speth, advisor, Defense 07/21/08) Department of Pharmacology.

8)    Xu Zhang – Dissertation Committee member (Dr. Wadkins, advisor Defense 12/04/08) Department of Chemistry.

9)    Lu Wang– Chair Dissertation Committee (Defense 07/23/09) Department of Pharmacology. Title: CYP1 expression in Fundulus heteroclitus following benzo(a)pyrene (BaP) exposure.

10) Sashi Kasimsetty– Dissertation Committee member (Dr. Ferreira, advisor, Defense 09/15/09) Department of Pharmacognosy.

11) Minghui Wu- Dissertation Committee member (Dr. Asok Dasmahapatra, advisor, Defense 06/25/10) Department of Pharmacology.

12) Xiefan Fang - Chair Dissertation Committee. Current student. (Defense 07/20/11) Department of Pharmacology. Title: Epigenetic effects of benzo[a]pyrene in Fundulus heteroclitus and Danio rerio.

13) Mona Heron –Dissertation Committee. (Advisor, Dr. Asok Dasmahapatra, Defense 07/15/13). Pharmacology. Title: Perspectives on Ethanol Toxicity in Medaka Embryogenesis and Possible Protection by Panax ginseng: Histological and Biochemical Analysis.

14) Cole Easson – Dissertation Committee (Advisors Drs. Marc Slattery and Deb Gochfeld, Defense 08/13). Title: Individual and population responses of the Caribbean sponge, Aplysina cauliformis, to natural and anthropogenic stressors.

15) Adam Hawkins – Chair Dissertation Committee. (Defense 06/27/14). Environmental Toxicology Graduate Program. Title: Effects of nanosilver and silver nitrate exposure on fathead minnows (Pimephales promelas) and zebrafish (Danio rerio).

16) Khalid Alharthy - Chair Dissertation Committee. (Defense 07/17/15) Department of Pharmacology. Topic of study: Physiological consequences of decreased aromatase activity.

17) Faisal Albaqami – Chair Dissertation Committee. (Defense 03/11/16) Environmental Toxicology Graduate Program. Topic of study: Effects of saffron constituents on prostate cancer in vitro and in vivo models.

18) Trisha Dhawan – Chair Dissertation Committee. Current Student. Division of Pharmacology.

19) Dennis Carty - Chair Dissertation Committee. Current Student. Division of Environmental Toxicology. Topic of study: Drug-resistant epilepsy: Efficacy vs Toxicity of Cannabidiol and Δ9-Tetrahydrocannabinol.

 

HIGH SCHOOL and UNDERGRADUATE STUDENT MENTORING

 

1)    Diana Kahle, Mississippi School for Math and Science. Summer 2001.

2)    Jason Hudson, an UM Forensic Chemistry major. Fall and Spring 2002.

3)    LaDiedra Jackson, an SRIU undergraduate Biology major from Mississippi Valley State University. Summer 2003.

4)    Scharri Ezell, an undergraduate Chemistry major from Tougaloo College, participated in the Ronald McNair Post-Baccalaureate Achievement Program. Summer 2004.

5)    Kimberly Jefferson, an SRIU undergraduate Biology major from Mississippi Valley State University. Summer 2004.

6)    Dolaclisha Ross and Wesley Bowen, undergraduate UM Forensic Chemistry majors, Fall 2004.

7)    Deborah Leslie, undergraduate UM Forensic Chemistry major, Fall 2005.

8)    Beth Emerson, undergraduate UM Forensic Chemistry major, Spring 2006.

9)    Hallie Freyaldenhoven, Mississippi School for Math and Science. Summer 2006.

10) Jacqueline Washington, undergraduate UM Forensic Chemistry major, Spring 2006.

11) Anna Marie Hailey undergraduate UM Forensic Chemistry major, Spring 2007.

12) Claire Rogers undergraduate Honors Forensic Chemistry major, Honors Thesis: Mechanisms of benzo[a]pyrene and a-napthoflavone embryo toxicity. Spring 2006 – 2007.

13) Adrienne Wells, an undergraduate Biology major from Tougaloo College, participated in the Ronald McNair Post-Baccalaureate Achievement Program and was a MFGN REO Summer student. Summer 2009.

14) Christina Schmalz Pryor, undergraduate UM Forensic Chemistry major, Spring 2009.

15) Danielle Nordurf, undergraduate Honors Forensic Chemistry major, Honors Thesis: “Effect of silver or nanosilver solutions on fish embryo or gill toxicity” Spring 2010 – 2011.

16) Catherine Freeland, undergraduate from Hanover College, IN. Summer 2011.

17) Mallory White, undergraduate Honors College and UM prepharmacy major. Honors Thesis: “Reproductive and multigenerational effects of dietary benzo[a]pyrene exposure in zebrafish.” Summer 2011 - 2014.

18) Kate Mislan, undergraduate pharmacy major, School of Pharmacy Summer Research Fellowship. Summer 2012.

19) Will Guyton, undergraduate UM Forensic Chemistry major, Spring 2013 – 2014.

20) Terika Tillman, an undergraduate Chemistry major from Tougaloo College, participated in the Ronald McNair Post-Baccalaureate Achievement Program. Summer 2013.

21) Kristen Dickerson, undergraduate UM Forensic Chemistry major, Spring 2014.

22) Jenn Shore, undergraduate UM Forensic Chemistry major, Spring 2014.

23) Tamara King, undergraduate UM Forensic Chemistry major, Spring 2014 – Fall 2014.

24) Autumn Burkett, undergraduate UM Chemistry major, Spring 2014 – Fall 2014.

25) Stacy Wolff, undergraduate Honors College and UM Forensic Chemistry major. Honors Thesis: “Mercury in fish in north Mississippi reservoirs: statistical analysis and risk assessment.” Fall 2013 – Spring 2014.

26) Natalia Ribeiro-Santos, Brazilian Pharmacy Exchange student, Fall 2013 – Spring 2014.

27) Nateasha Carter, an undergraduate Biology major from Tougaloo College, participated in the Ronald McNair Post-Baccalaureate Achievement Program. Summer 2015.

28) Sarah Castle, Lafayette High School Student, ARISE program. Summer 2015.

29) Kayla Frost, undergraduate UM Chemistry major, Fall 2015 – Spring 2016.

30) Tristan Daily, Mississippi School for Science and Math High School Student, ARISE program. Summer 2016.

31) James-Roland Markos, undergraduate Biochemistry major, COBRE-SURP Natural Products Neuroscience Summer Undergraduate Research Program. Summer 2016.

32) Mary Kathryn Pearson, undergraduate Honors College and UM pharmacy major. Summer 2016.

33) James Gledhill, undergraduate UM Chemistry major, Spring 2016 – Spring 2017.

34) Collin Dietrich, undergraduate Honors College and exercise science major. Spring 2016 – Spring 2017.

 

 

STUDENT AWARDS

Awards my University of Mississippi (under)graduate students have received:

 

Harshala Butala, 3rd Place Platform Award, 2002 Mid-South SETAC Annual Meeting.

 

Rooha Contractor, 1st Place Travel Award to National Meeting, 2002 Mid-South SETAC Annual Meeting.

 

Monali Patel, 3rd place Poster Award, 2003 Mid-South SETAC Annual Meeting.

 

Srinivas Annavarapu, 1st Place Platform Award, 2003 Mid-South SETAC Annual Meeting.

 

Zankhana Master, Poster Presentation Award, 2004 SEPS Regional Meeting.

 

Amit Chaudhary,

Best Poster Presentation, Biology Division, 2004 Sigma Xi Poster Session.

Travel Award to attend 2004 National Society of Toxicology Meeting.

Best Poster Presentation in Marine Sciences, 2005 Sigma Xi Poster Session.

Pritchard Award for Excellence in Graduate Studies, 2005 Department of Pharmacology.

SCSOT Technology Transfer Award ($250).

 

Beth Emerson, 2nd place Platform Award, 2006 Mid-South SETAC Annual Meeting.

1st place AAUW undergraduate poster 2006 Sigma Xi Poster Session.

 

Shiqian Zhu, SOT Travel Award ($500)

 

Cammi Thornton, 1st place Presentation Award, 2008 South Central Chapter Society of Toxicology.

 

Lu Wang, SETAC Travel Award ($275).

SOT Travel Award and SOT National Graduate Student Award (finalist).

SOT Toxicologic and Pathology Specialty Section Award ($1000)

Student Travel Award to the Society of Toxicologic Pathology Symposium.

 

Xiefan Fang, South Central SOT Travel Award ($300)

SETAC Travel Award

SOT Travel Award ($1000)

SCSOT Technology Transfer Award ($1000).

UM Graduate Student Research Award ($500)

UM Graduate Student Award (campus wide)

 

Frank Booc, SOT Reproductive and Developmental Toxicology Specialty Section Student Award ($100)

SCCSOT Travel Award Application ($500)

UM Graduate Student Research Grant ($1000).

1st place Biology Division, 2012 University of Mississippi Research Symposium.

 

Meghan Dailey, SETAC travel award   

 

Mallory White, UM Taylor Medal

 

Terika Tillman Undergraduate travel award for SCC-SOT; at the meeting she earned a – 1st place presentation award

 

Khalid Alharthy, 3rd place platform award, SCC-SOT regional meeting, 2014

 

Trisha Dahwan, Research Grant- Graduate School Council Research Grant, May 2016

Travel grant: Graduate School Council, SOT Annual meeting, March 2016

Awarded 3rd place best graduate student poster for GSC Research Forum poster presentation, April 2015

Travel grant: Reproductive and Developmental Toxicology Specialty Section (RDTSS), SOT Annual Meeting, March 2015

Travel grant- Graduate School Council, SOT Annual meeting, March 2015

 

Dennis Carty, COBRE graduate student fellowship program ($10,000), 2015

American College of Toxicology membership and graduate fellowship ($5000/year for two years plus travel costs to annual meeting) 2016

William Benson Outstanding Graduate Student in Environmental Toxicology Award 2016