AJIT SADANA

 

Professor of Chemical Engineering

University of Mississippi

University, MS 38677-9740

Tel: (662) 915-5349

Fax: (662) 915-7023

Email: cmsadana@olemiss.edu

 



EDUCATION

 

Ph. D., Chemical Engineering, University of Delaware, 1975.

M. Chem. E., Chemical Engineering, University of Delaware, 1972.

B. Tech., Chemical Engineering, Indian Institute of Technology, Kanpur, 1969.

 

RESEARCH INTERESTS

 

Antigen-Antibody and Analyte-Receptor Binding Kinetics for Biosensors and Cell-Surface Interactions

Fractal Analysis of ECGs and EEGs

Applied Mathematics and Modeling of Biological Systems

Interfacial Biological Reactions

Protein Folding and Misfolding- Biomedical Implications and Onset of Diseases

 

ACADEMIC EXPERIENCE

 

Professor, University of Mississippi, July 1990-present

Associate Professor, University of Mississippi, September 1981-June 1990.

Adjunct Associate Professor, University of Rhode Island, 1984-1987.

Visiting Associate Professor, Auburn University, 1980-1981.

 

NON-ACADEMIC EXPERIENCE

 

Research Fellow, Cardiology Division, National Heart, Lung, and Blood

Institute, NIH, Bethesda, Maryland, May-August 1999, July-August 2000.

Research Fellow, ORISE, Oak Ridge National Laboratory, Oak Ridge, TN, Summer 1994, 1995, 1996, 1997,1998, and 2000.

Distinguished Fellow, NAVY/ASEE, Naval Research Laboratory, Washington, DC, Summer 1991.

Senior Fellow, NAVY/ASEE, Naval Research Laboratory, Washington, DC, Summer 1990.

Visiting Research Scientist, E.I. DuPont de Nemours & Co., Experimental Station, Wilmington, DE, Summer 1988.

Senior Scientific Officer, National Chemical Laboratory, Poona, India, 1975-1980.

Project Engineer, Enviroengineering, Inc., Somerville, NJ, 1974-1975.

 

BOOKS

 

"Binding and Dissociation Kinetics for Different Biosensor Applications," Elsevier, Amsterdam, in press.

“Fractal Binding and Dissociation Kinetics for Different Biosensor Applications,” Elsevier, Amsterdam, The Netherlands, 2005.

"Biosensors: Kinetics of Binding and Dissociation Using Fractals," Elsevier, Amsterdam, The Netherlands, 2003.

"Engineering Biosensors: Kinetics and Design Applications," Academic Press, San Diego, California, 2001.

"Bioseparations of Proteins: Unfolding/Folding And Validations," Academic Press, San Diego, California, November 1997.

"Biocatalysis: Fundamentals of Enzyme Deactivation Kinetics," Prentice Hall, New Jersey, 1991.

 

HONORS

 

2004 Senior Faculty Research Award

Listed in American Men and Women of Science

Who's Who in the South and Southwest

Who's Who Among Asian Americans

International Directory of Distinguished Leadership

Most Admired Men and Women of the Year

Who's Who in the World

Who's Who in Science and Engineering

Who's Who in American Education

Dictionary of International Biography

Men of Achievement

International Who's Who of Contemporary Achievement

International Cultural Diploma of Honor

Who's Who in Finance and Industry

1996 Man of the Year

Five Hundred Leaders of Influence

Research Fellow, American Biographical Institute

Five Thousand Personalities of the World

 

CONSULTANT

 

First Chemical Corporation, Pascagoula, Mississippi

National Institutes of Health (NIH), Bethesda, Maryland

NBID Associates, Granville, Ohio

 

PUBLICATIONS

 

1.             Doke, A.M., Mathur, S.K., and Sadana, A., “Identification of Hair Cycle-Associated Genes from Time-Course Gene Expression Profile Using Fractal Analysis,” International Journal of Bioinformatics Research and its Applications, (in press).

2.             Doke, A.M. and Sadana, A., “Fractal Analysis of Heart-Related Compounds,” Journal of Receptors and Signal Transduction, (in press).

3.             Sadana, A. and Vo-Dinh, T., “A Fractal Analysis of Glucose and Related Analytes,” Nanotechnology in Biology and Medicine, ed. Vo-Dinh, T., CRC Press, Boca Raton, Florida (In press)

4.             Doke, A.M., and Sadana, A. ,”A Fractal Analysis of the Binding Kinetics of the Heat Shock Protein Chaperone DnaK on a SPR Biosensor Surface,” Encyclopedia of Sensors, Eds., M.V. Pishko and C.A. Grimes, American Scientific Publishers, California (in press)

5.             Sadana, A., Vo-Dinh, T., and Jeyashekar, N.S., “Protein Folding:  Biomedical Implications,” Encyclopedia of Chemical Processing, Ed. S.L. Lee, Taylor and Francis, New York, NY, 2006, pp. 2479-2488.

6.             Doke, A. M., and Sadana, A., “Detection of Glucose and Related Analytes by Biosensors: A Fractal Analysis,” Journal of Receptors and Signal Transduction, 26(1-2), 35-59 (2006).

7.             Doke, A. M., and Sadana, A., “Detection of Glucose and Related Analytes by Biosensors: A Fractal Analysis,” Biotechnology Progress, 22(1), 14-23 (2006).

8.             Sadana, A., Butala, H., Vo-Dinh, T., and Ramakrishnan, A., “Biosensor Surface Phenomenon,” Encyclopedia of Surface and Colloid Science, Ed. P. Somasundaran, Taylor and Francis, New York, NY, 2005, pp. 1-14.

9.             Ramakrishnan, A., Tan, Y., and Sadana, A., “A Kinetic Study Of Analyte-Receptor Binding And Dissociation For Surface Plasmon Resonance Biosensor Applications,” IEEE Sensors Journal, 5(3), 356-364 (2005).

10.         Morris, B. A., and Sadana, A., “A fractal analysis for the binding of riboflavin binding protein to riboflavin immobilized on a SPR biosensor,” Sensors and Actuators, B: Chemical, B106(2), 498-505 (2005).

11.         Morris, B. A., and Sadana, A., “A fractal analysis of pathogen detection by biosensors,” Biophysical Chemistry, 113(1), 67-81 (2005). 

12.         Jeyshekhar, N., Sadana, A., and Vo-Dinh, T., “Pathological Implications of Misfolded Proteins:  Amyloidoses,” Protein Nanotechnology Protocols, Methods in Molecular Biology, ed. Vo-Dinh, T., The Humana Press, Inc., Totowa, New Jersey, 2005; 300(Protein Nanotechnology),  pp. 416-435.

13.         Butala, H.D., Tan, Y., and Sadana, A., “Analyte-Receptor Binding On SPR Biosensors:  A Fractal Analysis of Cre-loxP Interactions and the Influence of Cl, O, and S, on Drug/Liposome Interactions,” Analytical Biochemistry, 332(1), 10-22 (2004). 

14.         Butala, H.D., and Sadana, A., “Binding and Dissociation Kinetics Using Fractals: an Analysis of Electrostatic Effects and Randomly Coupled and Oriented Coupled Receptors on Biosensor Surfaces” Biosensors & Bioelectronics, 19(8), 933-944 (2004).

 

15.         Butala, H.D., and Sadana, A., “Fractal Analysis of Binding Kinetics on Biosensor Surfaces,” Encyclopedia of Nanoscience and Nanotechnology, Eds., James A. Schwarz, C. Contescu, and K. Putyera, Marcel Dekker, New York, NY, 2004;  pp. 1191-1202.

16.         Jeyshekhar,N.S., and Sadana, A., "Kinetic Versus Thermodynamic Perspectives of Protein Folding Mechanisms and Drug Therapy," AIChE Annual Meeting, Conference Proceedings, San Francisco, CA (2003), pp. 20-34, American Institute of Chemical Engineers (publisher), New York, NY.

 

17.         Butala, H.D., Ramakrishnan, A., and Sadana, A., “A Fractal Analysis of Analyte-estrogen Receptor Binding and Dissociation Kinetics Using Biosensors: Environmental and Biomedical Effects,” Biosystems 70, 255-270 (2003).

 

18.         Butala, H.D., and Sadana, A., “A Fractal Analysis of Analyte-estrogen Receptor Binding and Dissociation Kinetics Using Biosensors: Environmental Effects,” Journal of Colloid & Interface Sci. 263, 420-431 (2003).

 

19.         Sadana, A., “A Fractal Analysis Of Protein To DNA Binding Kinetics Using Biosensors,” Biosensors & Bioelectronics, 18(8), 985-997 (2003).

 

20.         Butala, H.D., Ramakrishnan, A., and Sadana, A., ‘A Mathematical Analysis Using Fractals For Binding Interactions Of Estrogen Receptors To Different Ligands On Biosensor Surfaces,” Sensors & Actuators B, 85, 266-280 (2003).

 

21.         Ramakrishnan, A., and Sadana, A., “A Kinetic Study of Analyte-Receptor Binding And Dissociation Kinetics For Biosensor Applications: A Fractal Analysis For Two Different DNA Systems,” Biosystems, 66(3), 165-177 (2002).

 

22.         Butala, H.D., Ramakrishnan, A., and Sadana, A., “A Fractal Analysis Of Analyte-Receptor Binding And Dissociation Kinetics On Microcantilever Biosensors,” American Institute of Chemical Engineers Sensors Technology Conference Proceedings, eds., C.C. Liu, H.B. Martin, and J.C. Angus, New York, NY, pp. 31-39, November 3-8, 2002.

 

23.         Butala, H.D., Ramakrishnan, A., and Sadana, A., “A Kinetic Analysis Of Analyte-Receptor Binding And Dissociation Using Biosensors For Biomedical Applications, ” American Institute of Chemical Engineers Sensors Technology Conference Proceedings, eds., C.C. Liu, H.B. Martin, and J.C. Angus, New York, NY, pp. 93-101, November 3-8, 2002.

 

24.         Ramakrishnan, A., and Sadana, A., “A Kinetic Study Of Analyte-Receptor Binding And Dissociation For Biosensor Applications: A Fractal Analysis For Cholera Toxin And Peptide-Protein Interactions,” Sensors  & Actuators B, 85, 61-72 (2002). 

 

25.         Ramakrishnan, A. and Sadana, A., “A Mathematical Analysis Using Fractals And Biosensors For Binding Interactions Of Nuclear Estrogen Receptors (ER),” Anal. Biochem., 303(1), 78-92 (2002).

 

26.         English, M.J. and Sadana, A., “A Fractal Analysis Of Analyte-Receptor Binding And Dissociation Kinetics In Microcantilever Biosensors, “ Sensors & Actuators B, 4148, 1 (2002).

 

27.         Ramakrishnan, A. and Sadana, A., “Biosensors: An Emerging Tool In Analytical Research.  A Kinetic Analysis Of The Analyte-Receptor Interactions In Biosensors,” in Methods For Affinity Based Separations For Enzymes And Proteins, M.N. Gupta, ed., Birkhauser-Verlag, Berlin, p.195-216 (2002).

 

28.         Sadana, A. and Ramakrishnan, A., “A Kinetic Study Of Analyte-Receptor Binding And Dissociation For Surface Plasmon Resonance Biosensor Applications,” Proceedings IEEE Sensors 2002, Vol. 1, paper 38.1, June 11-14, 2002, Orlando, Florida.

 

29.         Sadana, A., "A Fractal Analysis Approach For The Evaluation Of Hybridization Kinetics In Biosensors," Journal of Colloid & Interface Sci., 234, 9 (2001).

 

30.         Sadana, A. and Vo-Dinh, T., “Biomedical Implications Of Protein Folding And Misfolding,” Biotechnol. & Appl. Biochemistry, 33, 7 (2001).

 

31.         Sadana, A. and Vo-Dinh, T., “A Kinetic Analysis Using Fractals Of Cellular Analyte-Receptor Binding And Dissociation,“ Biotechnol. & Appl. Biochem., 33, 17 (2001).

 

32.         Sadana, A., ”A Kinetic Study Of Analyte-Receptor Binding And Dissociation, And Dissociation Alone, For Biosensor Applications: A Fractal Analysis,” Anal. Biochem., 291(1), 34 (2001).

 

33.         Ramakrishnan, A. and Sadana, A., "A Single Fractal Analysis Of Cellular Analyte-Receptor Binding Kinetics Utilizing Biosensors,” Biosystems, 59(1), 35 (2001).

 

34.         Ramakrishnan, A. and Sadana, A., “A Fractal Analysis For Cellular Analyte-Receptor Binding Kinetics: Biosensor Applications,” Automedica, 20 (3-4), 313 (2001).

 

35.         Sadana, A., “A Fractal Analysis For Analyte-Receptor Binding Kinetics For Biosensor Applications,” Biotechnology & Genetic Engineering Reviews, Vol. 18, Chapter 2, S.E. Harding, Ed., Intercept Limited, Andover, Hampshire, U.K., pp. 29-48 (2001).

 

36.         Ramakrishnan, A. and Sadana, A., “Analyte-Receptor Binding And Dissociation Kinetics For Biosensor Applications: A Fractal Analysis,” Biosensors & Bioelectron., 15 (11-12), 651 (2000).

 

37.         Sadana, A., Ramakrishnan, A., and Vontel, S., "An Evaluation Of Hybridization Kinetics In Biosensors Using A Single Fractal Analysis," Biotechnology & Applied Biochemistry, 31(2), 161 (2000).

 

38.         Sadana, A. and Ramakrishnan, A., "A Predictive Approach Using Fractal Analysis For Analyte-Receptor Binding And Dissociation Kinetics For Surface Plasmon Resonance Biosensor Applications," J. of Colloid & Interface Sci., 229, 628 (2000).

 

39.         Ramakrishnan, A. and Sadana, A., “An Evaluation Of Cellular Analyte-Receptor Binding Kinetics Utilizing Biosensors: A Fractal Analysis,” J. Colloid & Interface Sci., 224, 219 (2000).

 

40.         Sadana, A., "Analysis Of The Kinetics Of Antigen-Antibody Interactions And The Fractal Dimension In Biosensors," In  Biosensors And Their Applications, eds., Ngo, T.T. and Yang, V.C., Chapter 2, Kluwer Academic/Plenum Publishing, New York, NY, pp.25-33 (2000).

 

41.         Ramakrishnan, A. and Sadana, A., "Economics Of Bioseparation Processes," Handbook of Bioseparations, Ahuja, S., ed., Separation Science & Technology Series, Academic Press, San Diego, CA, Chapter 18, pp. 667-685 (2000).

 

42.         Price, R. and Sadana, A., "Engineering Process Control Of Bioseparation Processes," Handbook of Bioseparations, Ahuja, S., ed., Separation Science & Technology Series, Academic Press, San Diego, CA , Chapter 17, pp. 659-665 (2000). 

 

43.         Sadana, A. "In-vitro and In-vivo Protein Folding Mechanisms," Methods in Non-Aqueous Enzymology, Gupta, M.N., ed., Birkhauser-Verlag, Basel, Switzerland, Chapter 12, pp. 195-211 (2000).

 

44.         Sadana, A. and Ramakrishnan, A. "Analyte-Receptor Binding Kinetics For Different Types Of Biosensors.  A Fractal Analysis," Appl. Biochem. & Biotechnol., 81(3),161 (1999).

 

45.         Sadana, A., "A Single- And A Dual-Fractal Analysis Of Antigen-Antibody Binding Kinetics For Different Biosensor Applications, " Biosensors & Bioelectron.14, 515-531 (1999).

 

46.         Ramakrishnan, A. and Sadana, A., "An Analysis Of Analyte-Receptor Binding Kinetics For Biosensor Applications: Influence Of The Fractal Dimension On The Surface On The Binding Rate Coefficient," Biotechnology and Appl. Biochem., 29 (1) 45 (1999). 

 

47.         Ramakrishnan, A. and Sadana, A., "A Single And A Dual-Fractal Analysis Of Analyte-Receptor Binding Kinetics For Surface Plasmon Resonance Biosensor Applications, J. Colloid & Interface Sci., 213, 465-478 (1999).

 

48.         Ramakrishnan, A. and Sadana, A., "Analyte-Receptor Binding Kinetics For Biosensor Applications:  A Single-Fractal And A Dual-Fractal Analysis Of The Influence Of The Fractal Dimension On The Binding Rate Coefficient," J. Colloid & Interface Sci., 208, 455 (1998).   

 

49.         Sadana, A., "An Analysis Of Analyte-Receptor Binding Kinetics For Biosensor Applications: Influence Of The Fractal Dimension On The Binding Rate Coefficient," Biosensors & Bioelectron., 13, 1127 (1998).

 

50.         Sadana, A., "An Analysis Of Analyte-Receptor Binding Kinetics For Biosensor Applications:  Influence Of The Fractal Dimension  On The Binding Rate Coefficient," J. Colloid & Interface Sci., 198, 164 (1998).

 

51.         Sadana, A., "Analyte-receptor Binding Kinetics For Biosensor Applications: An Analysis Of The Influence Of The Fractal Dimension On the Binding Rate Coefficient," Applied Biochem. & Biotechnol., 73(2-3), 89 (1998).

 

52.         Sadana, A. and Vo-Dinh, T., "Single- and Dual-Fractal Analysis of Hybridization Binding Kinetics:  Biosensor Applications," Biotechnol. Progr. , 14, 782-790 (1998).

 

53.         Sutaria, M. and Sadana, A., "Dual-Fractal Analysis For Antigen-Antibody Binding Kinetics For Biosensor Applications, "Biotechnol. Progr., 13, 464 (1997).

 

54.         Sadana, A., "Binding Kinetics For Biosensor Applications Utilizing Fractals: A Categorization," J. Colloid & Interface Sci., 190, 232 (1997).

 

55.         Sadana, A. and Sutaria, M., "Antigen-Antibody Binding Kinetics For Biosensor Applications:  A Dual-Fractal Analysis," Appl. Biochem. & Biotechnol., 62(2-3), 275 (1997).

 

56.         Sadana, A. and Vo-Dinh, T., "Antibody-Antigen Binding Kinetics. A Model For Multi-Valency Antibodies For Large Antigen Systems," Appl. Biochem. & Biotechnol., 67(1), 1 (1997).

 

57.         Sadana, A. and Sutaria, M., "Influence Of Diffusion To Fractal Surfaces On The Binding Kinetics For Antibody-Antigen, Analyte-Receptor, And Analyte-Receptorless (Protein) Systems, Biophys. Chem., 65, 29 (1997).

 

58.         Milum, J. and Sadana, A. "Influence Of Different Parameters On A Dual-Fractal Analysis For Antigen-Antibody Binding Kinetics For Biosensor Applications," J. Colloid & Interface Sci., 187, 128 (1997).   

 

59.         Sadana, A., Alarie, J.P., and Vo-Dinh, T., "Antigen-Antibody Diffusion-Limited Binding Kinetics For Biosensors: A Fractal Analysis," Sensors & Actuators B, 32, 195 (1996). 

 

60.         Sadana, A., and Beelaram, A., "Antigen-Antibody Binding Kinetics For Biosensor Applications:  Changes In The Fractal Dimension (Surface Roughness) And In The Binding Rate Coefficient," Appl. Biochem. & Biotechnol., 60(2), 123 (1996).

 

61.         Sadana, A. and Beelaram, A. "Antigen-Antibody Diffusion-Limited Binding Kinetics For Biosensors:  A Fractal Analysis," Appl. Biochem. & Biotechnol., 59, 259 (1996).

 

62.         Sadana, A. and Chen, Z., "Influence Of Non-Specific Binding On Antigen-Antibody Binding Kinetics For Biosensor Applications, "Biosens. & Bioelectron., 11, 17 (1996).

 

63.         Sadana, A. and Chen, Z., "A Fractal Analysis Of The Influence Of Non-Specific Binding On Antigen-Antibody Binding Kinetics For Biosensor Applications," Biosensors & Bioelectron., 11, 769 (1996). 

 

64.         Chen, Z. and Sadana, A., "An Analysis Of Antigen-Antibody Binding Kinetics For Biosensor Applications Utilized As A Model System:  Influence Of Non-Specific Binding," Biophys. Chem., 57, 177 (1996).

 

65.         Sadana, A. and Vo-Dinh, T., "Fractal Analysis For The Development Of Chemical Sensors For Environmental Monitoring, "European Symposium On Optics For Environmental & Public Safety Proceedings, eds., Vo-Dinh, T. and Werner, C., 19-23 June, 1995, Munich, FR Germany, SPIE Proceedings Series, Bellingham, WA (1995), p.480-485.

 

66.         Sadana, A., Alarie, J.P., and Vo-Dinh, T., "A β-cyclodextrin Based Fiber-Optic Chemical Sensor:  A Fractal Analysis," Talanta, 42, 1567 (1995). 

 

67.         Sadana, A., "Protein Refolding And Inactivation During Bioseparation:  Bioprocessing Implications," Proceedings of 'Recovery of Biological Products VII', San Diego, California, American Chemical Society, Washington, DC, Biotechnol. Bioengg., 48, 481 (1995).

 

68.         Sadana, A. and Beelaram, A., "Antigen-Antibody Diffusion-Limited Binding Kinetics For Biosensors:  A Fractal Analysis,"  Biosensors & Bioelectron., 10, 301 (1995).

 

69.         Sadana, A., "Antigen-Antibody Binding Kinetics For Biosensors: The Fractal Dimension And The Binding Rate Coefficient,"  Biotechnol. Progr., 11, 50 (1995).

 

70.         Sadana, A. and Beelaram, A., "High Resolution Fractionation Processes:  Chromatographic Techniques," Isolation and Purification, 2, 45 (1994).

 

71.         Sadana, A. and Beelaram, A., "Economics of Bioseparation: Some Case Studies," Bioseparation, 4, 221 (1994).

 

72.         Sadana, A. and Beelaram, A., "A Fractal Analysis Of Antigen-Antibody Binding Kinetics:  Biosensor Applications," Biotechnology Progress, 10, 291 (1994).

 

73.         Sadana, A., "Bioseparation Steps In Processing Proteins And Other Biological Processes.  Part 2,"  BioPharm, 7(3), 34 (1994).

 

74.         Sadana, A., "Bioseparation Steps In Processing Proteins And Other Biological Processes. Part 1," BioPharm, 7(2), 26 (1994).

 

75.         Sadana, A., "Protein Inactivations During Novel Bioseparation Techniques," Bioseparation, 4, 39 (1994).

 

76.         Sadana, A. and Madagula, A., "A Fractal Analysis Of The Influence Of A Time-Dependent Adsorption Rate Coefficient On External Diffusion Limited First-Order Kinetics For The Binding Of Antigen By Immobilized Antibody," Biosensors and Bioelectronics, 9, 45 (1994).

 

77.         Sadana, A., "Interfacial Protein Adsorption And Inactivation," Bioseparation, 3, 297 (1993).

 

78.         Sadana, A. and Madagula, A. "Binding Kinetics Of Antigen By Immobilized Antibody: Influence Of Lateral Interactions And Variable Rate Coefficients," Biotechnology Progress, 9, 259 (1993).

 

79.         Sadana, A. and Raju, R.R., "Effect Of Chemical Modification On Enzyme Activities And Stabilities," in Biocatalyst Design For Stability And Specificity, eds. M.E. Himmel and G. Georgiou, Chapter 24, p. 296, ACS, Washington, DC (1993).

 

80.         Sadana, A., "Inactivation Of Proteins And Other Biological Macromolecules During Chromatographic Methods Of Bioseparation, " Bioseparation, 3, 145 (1992).

 

81.         Sadana, A. and Sii, D., " Binding Kinetics Of Antigen By Immobilized Antibody: Influence Of Reaction Order And External Diffusional Limitations," Biosensors and Bioelectronics, 7, 559 (1992).

82.         Sadana, A., "Protein Adsorption and Inactivation on Surfaces. Influence of Heterogeneities," Chem. Rev., 92, 1799 (1992).

 

83.         Sadana, A., "Models Of Enzyme Deactivation," in Thermostability of Enzymes, ed. M.N. Gupta, Chapter 4, pp. 84-93, Narosa, New Delhi, 1992.

 

84.         Sadana, A. and Sii, D., "The Binding Of Antigen To Immobilized Antibody: Influence Of A Variable Adsorption Rate Coefficient On External Diffusion Limited Kinetics," J. Colloid Interface Sci., 151(1), 166 (1992).

 

85.         Sii, D. and Sadana, A., "Adsorption Of Proteins At Interfaces," J. of Microbial Biotechnol., 6(2), 16 (1991).

 

86.         Sadana, A., "Bioseparations Using Affinity Techniques," J. Biotech., 19, 83 (1991).

 

87.         Sadana, A. and Raju, R. R., "Protein/Enzyme Inactivation During Different Chromatographic Methods Of Separation," Bioseparations, 1, 119 (1990).

 

88.         Malhotra, A. and Sadana, A., "Role Of The Initial State Distribution On First-Order Deactivation Of Microheterogeneous Enzyme Samples," J. Theor. Biol., 145, 143 (1990).

 

89.         Sadana, A. and Malhotra, A., "Effect Of Enzyme Microheterogeneity On First-Order Deactivation And Conversion In Enzyme Reactors," J. Of Microbial Biotechnology, 4(1), 1 (1990).

 

90.         Sadana, A. and Raju, R.R., "Bioseparation And Purification Of Proteins: An Analysis Of Novel Techniques And Inactivating Influences," Biopharm, 3(5), 53 (1990).

 

91.         Henley, J.P. and Sadana, A., "Graphical Determination Of Mean Activation Energy And Standard Deviation In A Microheterogeneity Model Of Enzyme Deactivation," Biotech. Bioengg., 34, 916 (1989).

 

92.         Sadana, A. and Raju, R.R.," Stability Index For Enzymes Deactivating By Different Mechanisms," J. Biotechnol., 12, 327 (1989).

 

93.         Raju, R.R., Shahin, E., and Sadana, A.," A Stability Index For Enzyme Deactivations," J. Biotechnol., 12, 135 (1989).

 

94.         Chitnis, A. and Sadana, A., "pH-Dependent Enzyme Deactivation Models," Biotech. Bioengg., 34, 804 (1989).

 

95.         Malhotra, A. and Sadana, A., "Influence Of Diffusion On First-Order      Deactivation Of Microheterogeneous Enzyme Samples," Biotech. Bioengg., 34(5) 725 (1989).

 

96.         Sadana, A., "Protein Inactivation During Downstream Separation, Part II: The Parameters," Int. J. Pharm. Tech. Prod. Manuf. Pharm. Tech. Internat., 1(3), 34 (1989) (invited paper); Biopharm, 2(4), 20 (1989) (invited paper).

 

97.         Sadana, A., "Protein Inactivation During Downstream Separation,Part I: The Processes," Int. J. Pharm. Tech. Prod. Manuf. Pharm. Tech. Internat., 1(2), 29 (1989); Biopharm, 2(4)14 (1989) (invited paper).

 

98.         Sadana, A., "Enzyme Deactivation In Reactors," Biocatalysis, 2, 175 (1989).

 

99.         Malhotra, A. and Sadana, A., "Enzyme Microheterogeneity And Deactivation," Proceedings Of The International Conference On Advances In Chemical Engineering, Kanpur, India, January 4-6, 1989.

 

100.      Sadana, A., "Protease Inactivation During Downstream Processing,"    Biotechnology Research And Applications, Proceedings of CANBIOCON 88, Elsevier, Essex, England, p. 130 (1988).

 

101.      Sadana, A. and Malhotra, A., "Effect Of Enzyme Microheterogeneity On First-Order Deactivation And On Conversion In Enzyme Reactors," Enzyme Engineering IX Conference Proceedings, N.Y. Acad. of Sci., 542, 312 (1988).

 

102.      Sadana, A., "Enzyme Inactivations," Biotech. Advances, 6, 349 (1988).

 

103.      Sadana, A. and Henley, J.P., "An Analysis Of Enzyme Stabilization  By A Series-Type Mechanism. Influence Of pH,' J. Of Microbial Biotechnol., 3(1), 34 (1988).

 

104.      Sadana, A. and Malhotra, A., "Effect Of Enzyme Microheterogeneity Of Initial Enzyme States On First-Order Deactivation And On Conversion In Enzyme Reactors," Proceedings Of The 9th Symposium On Biotechnology For Fuels And Chemicals, Boulder, CO, ed. C.D. Scott, 17, Applied Biochemistry and Biotechnology, p. 335 (1988).

 

105.      Sadana, A., "Assessing Disguised Kinetics In Enzyme Deactivations," Trends In Biotechnology, 6(5), 84 (1988).

 

106.      Sadana, A., and Henley, J.P. "Influence Of pH On Enzyme Stabilization. An Analysis Using A Series-Type Mechanism," Journal Of Biotech., 7, 95 (1988).

 

107.      Sadana, A., "Enzyme Folding/Unfolding," Journal Of Biotech., 6, 107 (1987).

 

108.      Malhotra, A. and Sadana, A., "Single-Step Unimolecular First-Order Enzyme Deactivation Kinetics," Biotech. Bioengg., 30, 717 (1987).

 

109.      Malhotra, A. and Sadana, A., "Effect Of Activation Energy  Microheterogeneity On First-Order Deactivation," Biotech. Bioengg., 30, 108 (1987).

 

110.      Henley, J. P. and Sadana, A., "Influence Of Modifying Agents On Enzyme Inactivation Studies. An Analysis Using A Series Mechanism And Hill-Type Equations," Biotech. Advances, 5, 271 (1987).

 

111.      Sadana, A., and Henley, J.P., "Analysis Of Enzyme Deactivations By  A Series-Type Mechanism. Influence Of Modification On The Activity And Stability Of Enzymes," Proceedings Of The 8th International Enzyme Engineering Conference, NY Acad. Sci., 501, 73 (1987).

 

112.      Henley, J.P. and Sadana, A., "Influence Of Chemical Modification On Enzyme Inactivation Kinetics And Stability," 8th Symposium On Biotechnology For Fuels And Chemicals, ed. C.D. Scott, J. Wiley & Sons, p. 645 (1987).

 

113.      Sadana, A. and Henley, J.P., "Deactivation-Disguised Kinetics," J. Biotech., 5, 67 (1987).

 

114.      Henley, J.P. and Sadana, A., "On The Influence Of Severe Internal Diffusional Limitations On The Optimum Temperature Operations Criterion And Policies In Deactivating Fixed-Bed And Batch Reactors," Chem. Engg. Commun., 49(4-6), 291 (1987).

 

115.      Malhotra, A. and Sadana, A. "Microheterogeneity Of Enzymes And Deactivation," Biotechnol. Bioengg., 30, 1041 (1986).

 

116.      Sadana, A. and Henley, J.P., "Influence Of Modification On Enzyme Inactivation Kinetics And Stability," Biotech. Adv., 4, 22 (1986).

 

117.      Sadana, A. and Henley, J.P., "The Effect Of External Diffusional Limitations On Optimum Temperature Operations Policies In Deactivating Fixed-Bed Reactors," Chem. Engg. Commun., 46, 281 (1986).

 

118.      Henley, J.P. and Sadana, A., "Deactivation Theory," Biotech. Bioengg., 28, 1277 (1986).

 

119.      Henley, J.P. and Sadana, A., "Analysis Of The Effect Of Chemical Modification On The Activity And Stability Of Enzymes," 7th Symposium On Biotechnology For Fuels And Chemicals, ed. C.D. Scott., J. Wiley & Sons, p. 477 (1986).

 

120.      Henley, J.P. and Sadana, A., "A Mechanistic Analysis Of Complex Enzyme Deactivations. Influence Of Various Parameters On Series-Type Inactivations," Biotech. Bioengg., 28, 977 (1986).

 

121.      Sadana, A. and Henley, J.P., "Effect Of Chemical Modification On Enzyme Activities And Stabilities," Biotech. Bioengg., Biotech. Report, 28, 256 (1986).

 

122.      Henley, J.P. and Sadana, A., "A Mathematical Analysis Of The Influence Of Aging On Enzyme Deactivation Kinetics," Mech. Of Aging And Development, 32, 113 (1985).

 

123.      Henley J.P. and Sadana, A., "A Categorization Of Enzyme Deactivations By A Series-Type Mechanism," Enzyme And Microb. Tech., 7, 50 (1985).

 

124.      Sadana, A. and Henley, J.P., "A Mathematical Analysis Of Aging Influences On Enzyme Deactivation/Activation Kinetics. Examples Of The Influence Of Regional Brain Development And Drugs In Rats," Mech. Of Aging And Development, 30, 201 (1985).

 

125.      Sadana, A. and Henley, J.P., "A Mathematical Analysis Of Aging-Influenced Enzyme Deactivation Kinetics," Frontiers Of Engg. And Computing In Health Care, eds. J.C. Lin and B.N. Feinberg, 2, pp. 1022-29 (1985).

 

126.      Henley, J.P. and Sadana, A., "An Analysis Of Enzyme Stabilization By A Series-Type Mechanism. Influence Of Chemical Modifiers," 6th Symposium On Biotechnology For Fuels And Chemicals, ed. C.D. Scott, J. Wiley & Sons, p. 493 (1985).

 

127.      Henley, J.P. and Sadana, A.," Series-Type Enzyme Deactivation Kinetics. Influence Of Immobilization, Chemical Modifiers, And Enzyme Aging," New York Academy Of Sciences, Proceedings Of The Enzyme Engineering VII Conference, 434, 64 (1985).

 

128.      Henley, J.P. and Sadana, A., "An Analysis Of Enzyme Deactivation By A Series-Type Mechanism," Proceedings Of The IEEE 1984 Frontiers Of Engineering In Health Care Conference, eds. J.L. Semmlow and Welkowitz, Alliance For Engg. In Medicine And Biology, Publishers, Bethesda, MD, pp. 825-830 (1984).

 

129.      Henley, J.P. and Sadana, A., "Series-Type Enzyme Deactivations," Cell And Molec. Biol. Of Plant Stress, UCLA Symposium Series, 2, 64 (1984).

 

130.      Henley, J.P. and Sadana, A., "A Mathematical Analysis Of Enzyme Stabilization By A Series-Type Mechanism. Influence Of Chemical Modifiers," Biotech. Bioengg., 26, 959 (1984).

 

131.      Henley, J.P. and Sadana, A., "Series-Type Enzyme Deactivations. Influence Of Intermediate Activity On Deactivation Kinetics," Enzyme And Microb. Tech., 6(1), 35 (1984).

 

132.      Henley, J.P. and Sadana, A., "Influence Of Intermediate Activity On Series-Type Enzyme Deactivation Kinetics," Proceedings Of The Fifth Symposium On Biotechnology For Fuels And Chemicals, ed. C.D. Scott, J. Wiley & Sons, NY, p. 277 (1984).

 

133.      Henley, J.P. and Sadana, A., "Influence Of Intermediate Activity On Series-Type Enzyme Deactivations. Biomedical Applications," Proceedings Of The Second Southern Biomedical Engineering Conference, ed. William C. Hall, Pergamon Press, NY, p. 143 (1983).

 

134.      Sadana, A., "Influence Of Optimum Temperature Operations Policies On Deactivation And Reaction," Proceedings Of The IASTED International Symposium: ASM 83- Applied Simulation And Modeling, San Francisco, Acta Press, Zurich, p. 45-50 (1983).

 

135.      Sadana, A., "A Deactivation Model Involving A Grace Period For Immobilized And Soluble Enzymes," Enzyme And Microbial Technology, 4(1), 44 (1982).

 

136.      Sadana, A., "The Optimum Temperature Policy For A Deactivating Catalytic Packed-Bed Reactor. An Improved Method Of Operations," Chem. Engg. Sci., 37(3), 492 (1982).

 

137.      Patwardhan, V.S. and Sadana, A., "An Optimum Temperature Policy For A Deactivating Immobilized Enzyme Fixed-Bed Reactor," Chem. Engg. Commun., 15(1-4), 169 (1982).

 

138.      Sadana, A., "On A Simple Probabilistic Approach To Enzyme Deactivations," Ind. Engg. Chem. Fundamentals, 20(4), 336 (1981).

 

139.      Kulkarni, B.D., Sadana, A., and Ramachandran, P.A., "Analysis Of Multiple Steady-States Of Complex Biochemical Reactions," J. Appl. Chem. Biotech., 31(9), 546 (1981).

 

140.      Sadana, A., "A Theoretical Analysis Of The Deactivation Of An Immobilized Enzyme In Multi-Enzyme Reactions In Fixed- And Fluid-Bed Reactors," J. Appl. Chem. Biotech., 31(9), 553 (1981).

 

141.      Sadana, A., "Catalytic Oxidation Of Maleic Acid In Aqueous Solution," Ind. Engg. Chem. Proc. Des. Develop., 20, 397 (1981).

 

142.      Sadana, A., "Critical Catalyst Concentration In Liquid-Phase Hydrocarbon Oxidations," Ind. Engg. Chem. Proc. Des. Develop. 20, 397 (1981).

 

143.      Sadana, A., "A Deactivation Protection Model For Immobilized And Soluble Enzymes," Enzyme And Microbial Technology, 3, 357 (1981).

 

144.      Sadana, A., Kulkarni, B.D., and Ramachandaran, P.A., "Criteria For Multiple Steady-States For Allosteric Enzyme Systems," Chem. Engg. Commun., 7(6), 389 (1980).

 

145.      Sadana, A., "The Optimum Temperature Operations Policy For A Deactivating Moving-Bed Reactor," Proceedings Of The 4th National Symposium On Catalysis, India, 279 (1980).

 

146.      Sadana, A., "Deactivation Model For Immobilized And Soluble Enzymes," Biotechnology Letters, 2(6), 279 (1980).

 

147.      Sadana, A., "On Critical Catalyst Concentration In Aqueous-Phase Phenol Oxidation," Ind. Engg. Chem. Proc. Des. Develop., 19(2), 324 (1980).

 

148.      Sadana, A., "On Optimum Temperature Operations In Deactivating Fixed-Bed Reactors," Chem. Engg. Commun., 4(1), 51 (1980).

 

149.      Sadana, A., "A Generalized Optimum Temperature Operations Criterion For Deactivating Immobilized Enzyme Batch Reactors," AIChE J., 25(3), 535 (1979).

 

150.      Sadana, A., "An Analysis Of the Heterogeneously-Catalyzed Free-Radical Oxidation Of Phenol In Aqueous Solution," Ind. Engg. Chem. Proc. Des. Develop., 18, 50 (1979).

 

151.      Sadana, A., "A pH-Dependent Deactivation Model For Immobilized And Soluble Enzymes," Biotech. Letters, 1(11), 465 (1979).

 

152.      Levenspiel, O. and Sadana, A., "An Optimum Temperature Policy For A Deactivating Fixed-Bed Reactor. A Reply," Chem. Engg. Sci., 34, 1177 (1979).

 

153.      Sadana, A., "Intra-Particle Diffusion Effects In Heterogeneously-Catalyzed Aqueous-Phase Phenol Oxidation," Can. J. Chem. Engg., 56, 762 (1978).

 

154.      Sadana, A., "Effect Of Immobilized Enzyme Deactivation In Fixed-, Moving-, And Fluid-Bed Reactors," Biotech. Bioengg., 20(6), 781 (1978).

 

155.      Levenspiel, O. and Sadana, A., "The Optimum Temperature Policy For A Deactivating Catalytic Packed-Bed Reactor," Chem. Engg. Sci., 33(10), 1393 (1978).

 

156.      Katzer, J.R., Sadana, A., and Ficke, H.H., "Evaluation Of Catalytic Oxidation As A Wastewater Treatment Technique," J. Water Pollution Control Feder., 48, 920 (1975).

 

157.      Sadana, A. and Katzer, J.R., "Involvement Of Free Radicals In The Heterogeneously-Catalyzed Oxidation Of Phenol In Aqueous Solution," J. Catal., 35, 140 (1974).

 

158.      Sadana, A. and Katzer, J.R., "Catalytic Oxidation Of Phenol In Aqueous Solution," Ind. Engg. Chem. Fundam., 13, 127 (1974).

 

159.      Sadana, A. and Doraiswami, L.K., "Effect Of Catalyst Fouling In Fixed-, Moving-, And Fluid-Bed Reactors," J. Catal., 23, 147 (1971).

 

160.      Sadana, A. and Doraiswami, L.K., "A Generalized Effectiveness Factor Plot For Second-Order Reactions," Chem. Age Of India, 22, 85 (1971).

 

 

PAPERS PRESENTED

 

1.             Doke, A.M., Morris, B.A., and Sadana, A., “A Fractal Analysis of Pathogen Detection,” Defense and Security Symposium, An SPIE Event, Orlando (Kissimmee), Florida. April 17-21 2006.

2.             Doke, A.M., and Sadana, A., “Fractal Binding and Dissociation Kinetics of Heart-Related Compounds on Biosensor Surfaces,” Defense and Security Symposium, An SPIE Event, Orlando (Kissimmee), Florida. April 17-21 2006.

3.             Doke, A.M., and Sadana, A., "Fractal Binding and Dissociation Kinetics of Heart-Related Compounds on Biosensor Surfaces,” Eleventh Annual Institute of Biological Engineering Meeting, Tucson, Arizona, March 10-12, 2006.

4.             Doke, A.M., and Sadana, A., “Binding Kinetics of Free- and Total-Prostate Specific Antigen by Biosensors Using Fractal Analysis,” Eleventh Annual Institute of Biological Engineering Meeting, Tucson, Arizona, March 10-12, 2006.

5.             Sadana, A., and Doke, A.M., “Detection of Glucose and Related Analytes by Biosensors: a Fractal Analysis” Annual AIChE Meeting, Cincinnati, Ohio, October 30-November 4, 2005.

6.             Sadana, A., and Doke, A.M., “Fractal Analysis of Heparin-Protein Interaction Studies Occurring on Biosensor Surfaces” Annual AIChE Meeting, Cincinnati, Ohio, October 30-November 4, 2005.

7.             Sadana, A., and Doke, A.M., “A Fractal Analysis of Binding and Dissociation Kinetics of Glucose and Related Analytes on Biosensor Surfaces,” Tenth Annual Institute of Biological Engineering Meeting, Athens, Georgia, March 4-6, 2005

8.             Morris, B.A., and Sadana, A. “Binding and Dissociation Kinetics Using Fractals to Analyze Electrostatic Effects and Randomly Coupled and Oriented Coupled Receptors on Biosensor Surfaces: Implications in Autoimmune Diseases” 12th International Congress of Immunology and 4th Annual Conference of FOCIS, Montreal, Quebec, Canada, July 18-23, 2004.

9.             Morris, B.A., and Sadana, A. “A Kinetic Study of Analyte-Receptor Binding and Dissociation for Surface Plasmon Resonance Biosensor Applications”, The 11th International Conference on Human Antibodies & Hybridomas, Dublin, Ireland, October 6-8, 2004.

1.             Tan, Y., Butala, H.D., and Sadana, A., "Analyte-Receptor Binding On SPR Biosensors:  A Fractal Analysis of Cre-loxP Interactions and the Influence of Cl, O, and S, on Drug/Liposome Interactions," Annual AIChE Meeting, San Francisco, California, November 16-21, 2003.

2.             Tan, Y., and Sadana, A., “Analyte-Receptor Binding Kinetics on Microarrays: Environmental Applications” Annual AIChE Meeting, San Francisco, California, November 16-21, 2003.

3.             Jeyshekhar, N. and Sadana, A., “Pathological Implications of Misfolded Proteins-Amyloidosis”, Annual AIChE Meeting, San Francisco, California, November 16-21, 2003.

4.             Jeyshekhar, N. and Sadana, A., “Kinetic Versus Thermodynamic Perspective of Protein Folding Mechanisms and Drug Therapy”, Annual AIChE Meeting, San Francisco, California, November 16-21, 2003.

5.             Gir, S., Ramakrishnan, A., and Sadana, A. “Binding and Dissociation Kinetics Using Fractals: an Analysis of Electrostatic Effects and Randomly Coupled and Oriented Coupled Receptors on Biosensors Surface” Annual AIChE Meeting, San Francisco, California, November 16-21, 2003.

6.             Ramakrishnan, A., and Sadana, A. “Evaluation Of Hybridization Kinetics For biosensor Applications:  A Fractal Analysis,” Annual AIChE Meeting, Indianapolis, Indiana, November 3-8, 2002.

 

7.             Ramakrishnan, A. and Sadana, A., “A Fractal Analysis Of Analyte-Receptor Binding And Dissociation Kineics In Microcantilever Biosensors,” Annual AIChE Meeting, Indianapolis, Indiana, November 3-8, 2002.

 

8.             Ramakrishnan, A., Butala, H.D., and Sadana, A., “A Kinetic Analysis For Binding Interactions Of Nuclear Estrogen Receptors Occurring On Biosensor Surfaces,” Annual AIChE Meeting, Indianapolis, Indiana, November 3–8, 2002.

 

9.             Ramakrishnan, A., Gir, S., and Sadana, A., “ An Analysis Of Cell-Ligand And Ligand-Receptor Interactions Occurring In Parallel Using Biosensors,” Annual AIChE Meeting, Indianapolis, Indiana, November 3-8, 2002.

 

10.         Ramakrishnan, A., Butala, H.D., and Sadana, A., “A Kinetic Analysis Of Analyte-Estrogen Receptor Binding And Dissociation Using Biosensors For Biomedical Applications,” Annual AIChE Meeting, Indianapolis, Indiana, November 3-8, 2000.

 

11.         Ramakrishnan, A. and Sadana, A., “A Kinetic Study Of Analyte-Receptor Binding And Dissociation For DNA Biosensor Systems, “ Annual AIChE Meeting, Indianapolis, Indiana, November 3-8, 2002.

 

12.         Butala, H.D., Ramakrishnan, A., and Sadana, A., “A Fractal Analysis Of Analyte-Estrogen Receptor Binding And Dissociation Kinetics Using Biosensors: Environmental Effects,” Indianapolis, Indiana, November 3-8, 2002.

 

13.         Ramakrishnan, A., and Sadana, A., “A Single-Fractal Analysis Of Cellular Antigen-Antibody Binding Kinetics (Immunokinetics) Utilizing Biosensors,” Annual AIChE Meeting, Reno, Nevada, November 5-9, 2001.

 

14.         Ramakrishnan, A., and Sadana, A., “Protein Folding and Misfolding: Biomedical Implications,” Annual AIChE Meeting, Reno, Nevada, November 5-9, 2001.

 

15.         Ramakrishnan, A., and Sadana, A., “A Kinetic Study Of Analyte-Receptor Binding And Dissociation For (DNA) Biosensor Applications,“ Annual AIChE Meeting, Reno, Nevada, November 5-9, 2001.

 

16.         Ramakrishnan, A., and Sadana, A., “Evaluation Of Hybridization Kinetics For Biosensor Applications: A Fractal Analysis,” Annual AIChE Meeting, Reno, Nevada, November 5-9, 2001.

 

17.         Ramakrishnan, A., and Sadana, A., “A Kinetic Study Of Binding And Dissociation Of Cholera Toxin And Peptide-Protein Interactions For Biosensor Applications,“ Annual AIChE Meeting, Reno, Nevada, November 5-9, 2001.

 

18.         Ramakrishnan, A. and Sadana, A., “A Single and a Dual-Fractal Analysis Of Analyte-Receptor Binding Kinetics For Surface Plasmon Resonance Biosensor Applications”, 11th International Conference on Immunology, Stockholm, Sweden, July 22-27, 2001.

 

19.         Ramakrishnan, A., and Sadana, A., “Evaluation of Hybridization Kinetics In Biosensors Using A Single-Fractal Analysis,“ 11th International Conference on Immunology, Stockholm, Sweden, July 22-27, 2001.

 

20.         Ramakrishnan, A. and Sadana, A., “A Kinetic Analysis Using Fractals Of Analyte-Receptor Binding And Dissociation For Biosensor Applications,” 11th International Conference on Immunology, Stockholm, Sweden, July 22-27, 2001.

 

21.         Sadana, A., Fananapazir, L., and Ramakrishnan, A., “Risk Stratification Of Family Members At Risk of Hypertrophic Cardiomyopathy: A Fractal Analysis,” Inverse Problems in Engineering Symposium, Texas A & M University, June 14-16, 2001.

 

22.         Sadana, A. and Ramakrishnan, A., ”Analyte-Receptor (Drug-Receptor) Interactions Utilizing Biosensors,” Annual AIChE meeting, November 12-17, 2000.

 

23.         Sadana, A. and Ramakrishnan, A., “A Fractal Analysis for Evaluating Hybridization Kinetics in Biosensors,” Annual AIChE meeting, November 12-17, 2000.

 

24.         Sadana, A. and Ramakrishnan, A., “A Biomedical Diagnosis Predictive Approach Using Fractal Analysis: Study of Cardiac Recordings,“ Annual AIChE meeting, November 12-17, 2000.

 

25.         Sadana, A. and Ramakrishnan, A., “A Fractal Analysis for Analyte-Receptor Binding and Dissociation Kinetics for Surface Plasmon Resonance Biosensor Applications,” Annual AIChE meeting, November 12-17, 2000.

 

26.         Sadana, A. and Ramakrishnan, A., “Analysis of Cellular Analyte-Receptor Interactions for Biosensor Applications: A Fractal Approach,“ Annual AIChE meeting, November 12-17, 2000.

 

27.         Sadana, A. and Ramakrishnan, A., “Analyte-Receptor Binding and Dissociation Kinetics for Biosensor and Biomedical Applications,“ Annual AIChE meeting, November 12-17, 2000.  

 

28.         Sadana, A. and Ramakrishnan, A., "A Fractal Analysis For Cellular Analyte-Receptor Binding Kinetics Utilizing Biosensors," Annual AIChE Meeting, Dallas, November 1-5, 1999.

 

29.         Sadana, A. and Ramakrishnan, A., "A Fractal Analysis Of Analyte-Receptor Binding Kinetics For Surface Plasmon Resonance Biosensor Applications," Annual AIChE Meeting, Dallas, November 1-5, 1999.

 

30.         Sadana, A. and Vo-Dinh, T., "A Fractal Analysis Of Hybridization Kinetics In Biosensors," Annual AIChE Meeting, Dallas, November 1-5, 1999.

 

31.         Sadana, A. and Ramakrishnan, A., "An Evaluation Of Cellular Analyte-Receptor Binding Kinetics Utilizing Biosensors:  A Fractal Analysis," Annual AIChE Meeting, Dallas, November 1-5, 1999.

 

32.         Sadana, A. and Vo-Dinh, T., "Evaluation Of The Hybridization Kinetics In Biosensors Using Fractals," Annual AIChE Meeting, November 1-5, 1999.

 

33.         Sadana, A., "Importance Of The Medium For In-Vitro and In-Vivo Protein Folding Mechanisms," Annual AIChE Meeting, Dallas, November 1-5, 1999.

 

34.         Sadana, A., "Adsorption And Inactivation Of Proteins During Bioseparation," National Seminar on Bioprocessing And Recombinant Technology, Central Drug Research Institute, Lucknow, India, March 27-28, 1998.

 

35.         Sadana, A., "An Analysis Of Analyte-Receptor Binding Kinetics For Biosensor Applications:  Influence Of The Fractal Dimension On The Binding Rate Coefficient," National Seminar on Bioprocessing And Recombinant Technology, Central Drug Research Institute, Lucknow, India, March 27-28, 1998.

 

36.         Sadana, A., "A Categorization Of Antigen-Antibody Binding Kinetics At Solid-Liquid Interfaces. Applications Of Fractals To Biosensors," Annual AIChE Meeting, Los Angeles, November 16-21, 1997.

 

37.         Sadana, A., "Antigen-Antibody Binding Kinetics At Solid-Liquid  Interfaces:  A Categorization For Biosensor Applications Using Fractals," Annual AIChE Meeting, Los Angeles, November 16-21, 1997.

 

38.         Sadana, A. and Milum, J., "Influence Of Different Parameters On A Dual-Fractal Analysis For Antigen-Antibody Binding Kinetics For Biosensor Applications," Annual AIChE Meeting, Los Angeles, November 16-21, 1997.

 

39.         Sadana, A., "A Categorizaton Of Antigen-Antibody Binding Kinetics At Solid-Liquid Interfaces:  Applications Of Fractals To Biosensors," Transport at Interfaces Symposium, Annual AIChE Meeting, Los Angeles, November 16-21, 1997.

 

40.         Sadana, A., "Binding Kinetics For Biosensor Applications Utilizing Fractals:  A Categorization," Topical Conference on Separation Science & Technologies, Annual AIChE Meeting, Los Angeles, November 16-21, 1997.

 

41.         Sadana, A. and Sutaria, M., "Influence Of Diffusion To Fractal Surfaces On The Binding Kinetics For Antibody-Antigen, Analyte-Receptor, And Analyte-Receptorless (Protein) Systems," Annual AIChE Meeting, Chicago, IL, November 10-15, 1996.   

 

42.         Sadana, A. and Chen, Z., "A Fractal Analysis Of The Influence Of Non-Specific Binding On Antigen-Antibody Binding Kinetics For Biosensor Applications," Annual AIChE Meeting, Chicago,IL, November 10-15, 1996.   

 

43.         Sadana, A., "High-Resolution Fractionation Processes: Chromatographic Techniques," Annual AIChE Meeting, Chicago, IL, November 10-15, 1996.      

 

44.         Sadana, A., "Antigen-Antibody Binding Kinetics For Biosensors: Changes In The Fractal Dimension (Surface Roughness) And In The Binding Rate Coefficient," Annual AIChE Meeting, Miami Beach, November 12-17, 1995. 

 

45.         Sadana, A., "Antigen-Antibody Binding Kinetics For Biosensors:  The Fractal Dimension And The Binding Rate Coefficient," Annual AIChE Meeting, Miami Beach, November 12-17, 1995.

 

46.         Sadana, A. and Chen, Z., "Influence Of Non-Specific Binding On Antigen-Antibody Binding Kinetics For Fiber-Optic Biosensor Applications," Annual AIChE Meeting, Miami Beach, November 12-17, 1995.

 

47.         Sadana, A. and Chen, Z., "A Fractal Analysis Of The Influence Of Non-Specific Binding On Antigen-Antibody Binding Kinetics For Fiber-Optic Biosensor Applications," Annual AIChE Meeting, Miami Beach, November 12-17, 1995.

 

48.         Sadana, A. and Beelaram, A., "Antigen-Antibody Diffusion-Limited Binding Kinetics For Biosensors:  A Fractal Analysis," Annual AIChE Meeting, Miami Beach, November 12-17, 1995.  

 

49.         Sadana, A., "High-Resolution Fractionation Processes," Annual AIChE Meeting, Miami Beach, November 12-17, 1995.

 

50.         Sadana, A., Alarie, J.P., and Vo-Dinh, T., "Fractal Analysis For The Development Of Chemical Sensors For Environmental Monitoring," European Symposium on Optics For Environmental And Public Safety," Munich, FR Germany, June 19-23, 1995.

 

51.         Sadana, A. and Beela Ram, A., "Antigen-Antibody Binding Kinetics For Biosensor Applications:  A Fractal And Engineering Analysis," Annual AIChE Meeting, San Francisco, California, November 13-18, 1994.

 

52.         Sadana, A. and Beela Ram, A., "Antigen-Antibody Binding Kinetics For Biosensor Applications.  An Analysis Using The Nyikos-Pajkossy Equation For Diffusion Towards Fractal Surfaces," Annual AIChE Meeting, San Francisco, California, November 13-18, 1994.

 

53.         Sadana, A., "Protein Refolding Strategies," Annual AIChE Meeting, San Francisco, California, November 13-18, 1994.

 

54.         Sadana, A., "Protein Refolding And Inactivation During Bioseparation:  Bioprocessing Implications," Recovery of Biological Products VII, San Diego, CA, September 25-30, 1994, American Chemical Society.

 

55.         Sadana, A. and Beela Ram, A., "Antigen-Antibody Binding Kinetics For Biosensor Applications:  An Analysis Using The Nyikos-Pajkossy Equation For Diffusion Towards Fractal Surfaces," Biosensors 94, New Orleans, June 1-3, 1994.

 

56.         Sadana, A., "Protein Adsorption And Inactivation On Surfaces. Influence of Heterogeneities On Blood Protein Adsorption," Annual AIChE Meeting, St. Louis, November 7-12, 1993.

 

57.         Sadana, A., "Binding Kinetics Of Antigen By Immobilized Antibody Or Of Antibody By Immobilized Antigen: Influence Of Lateral Interaction And Variable Rate Coefficients," Annual AIChE Meeting, St. Louis, November 7-12, 1993.

 

58.         Sadana, A., "Protein Adsorption On Biomaterials," Annual AIChE Meeting, St. Louis, November 7-12, 1993.

 

59.         Sadana, A., "Protein Conformational And Activity Changes During Adsorption.  Bioseparation Implications," Annual AIChE Meeting, St. Louis, November 7-12, 1993.

 

60.         Sadana, A., "A Fractal Analysis Of External Diffusion Limited First-Order Kinetics For The Binding Of Antigen By Immobilized Antibody," Annual AIChE Meeting, St. Louis, November 7-12, 1993.

 

61.         Sadana, A., "Protein Adsorption And Inactivation At Interfaces. Influence Of Heterogeneities," Annual AIChE Meeting, Miami Beach, November 1-6, 1992.

 

62.         Sadana, A., "Inactivation Of Proteins And Other Biological Macromolecules During Chromatographic Methods Of Bioseparation" Annual AIChE Meeting, Miami Beach, November 1-6, 1992.

 

63.         Sadana, A. and Sii, D., "Binding Kinetics Of Antigen By Immobilized Antibody: Influence Of Reaction Order And External Diffusional Limitations," Annual AIChE Meeting, Los Angeles, CA, November 17-22, 1991.

 

64.         Sadana, A., "The Binding Kinetics Of Antigen By Immobilized Antibody Or Of Antibody By Immobilized Antigen. Influence Of Lateral Interactions," Annual AIChE Meeting, Los Angeles, CA, November 17-22, 1991.

 

65.         Sadana, A. and Sii, D., "The Binding Kinetics Of Antigen By Immobilized Antibody: Influence Of A Variable Rate Coefficient On External Diffusion Limited Kinetics," Annual AIChE Meeting, Los Angeles, CA, November 17-22, 1991.

 

66.         Sadana, A. and Sii, D., "Influence Of Diffusional Limitations On The Binding Kinetics Of Antibody In Solution By Immobilized Antigen" Annual AIChE Meeting, Los Angeles, CA, November 17-22, 1991.

 

67.         Sadana, A. and Raju, R.R., "Bioseparation And Purification Of Proteins: An Analysis Of Novel Techniques And Inactivating Influences," Annual AIChE Meeting, Chicago, IL, November 11-16, 1990.

 

68.         Sadana, A. and Raju, R.R., "Protein/Enzyme Inactivation During Different Chromatographic Methods Of Separation," Annual AIChE Meeting, Chicago, IL, November 11-16, 1990.

 

69.         Malhotra, A. and Sadana, A., "Role Of The Initial State Distribution On First-Order Deactivation Of Microheterogeneous Enzyme Samples," Annual AIChE Meeting, Chicago, IL, November 11-16, 1990.

 

70.         Sadana, A., "Protease Inactivation During Downstream Separation," Annual AIChE Meeting, Washington, DC, November 27-December 2, 1988.

 

71.         Sadana, A., "Inactivation Of Proteins and Enzymes During Bioseparation," Annual AIChE Meeting, Washington, DC, November 27-December 2, 1988.

 

72.         Malhotra, A. and Sadana, A., "Influence Of Microheterogeneity On Enzyme Deactivation," Annual AIChE Meeting, Washington, DC, November 27-December 2, 1988.

 

73.         Sadana, A., "Proteins/Enzymes Inactivation At Air-Liquid And Gas-Liquid Interfaces," Annual AIChE Meeting, Washington, DC,  November 27-December 2, 1988.

 

74.         Sadana, A., "Protease Inactivation During Downstream Processing," CANBIOCON 88, Montreal, April, 1988.

 

75.         Sadana, A. and Malhotra, A., "Effect Of Enzyme Microheterogeneity And Distribution Of Initial Enzyme States On First-Order Deactivation And Conversion In Enzyme Reactors," 9th Symposium On Biotechnology For Fuels And Chemicals, Boulder, CO, May 5-8, 1987.

 

76.         Sadana, A. and Henley, J.P., "Effect Of Enzyme Microheterogeneity  On First-Order Deactivation And On Conversion In Enzyme Reactors," Ninth International Conference On Enzyme Engineering, Santa Barbara, CA, October 4-9, 1987.

 

77.         Sadana, A., "Effect Of Severe Intra-Particle Diffusional Limitations On Optimum Temperature Operations Policies In Deactivating Fixed-Bed Reactors," Annual AIChE Meeting, New York, NY, November 15-20, 1987.

 

78.         Sadana, A. and Henley, J.P., "Deactivation-Disguised Kinetics," 39th Conference On Engg. In Medicine And Biology, Baltimore, MD, September 13-16, 1986.

 

79.         Sadana, A. and Henley, J.P., "Influence Of Chemical Modification On Enzyme Inactivation Kinetics And Stability," 8th Symposium On Biotechnology For Fuels And Chemicals, Gatlinburg, TN, May 16-18, 1986.

 

80.         Sadana, A. and Henley, J.P., "Deactivation Theory," National AIChE Meeting, Boston, MA, August 24-27, 1986.

 

81.         Sadana, A. and Henley, J.P., "A Mathematical Analysis Of Aging-Influenced Enzyme Deactivation Kinetics," 7th Annual EMBS Conference, Chicago, IL, September 27-30, 1985.

 

82.         Sadana, A. and Henley, J.P., "Analysis Of Enzyme Deactivations By A Series-Type Mechanism," 8th International Enzyme Engineering Conference, Helsingor, Denmark, September 22-27, 1985.

 

83.         Sadana, A. and Henley, J.P., "Influence Of Enzyme Modification On The Activity And Stability Of Enzymes. An Analysis By A Series-Type Mechanism," Biotech 85, Geneva, Switzerland, May 21-23, 1985.

 

84.         Sadana, A. and Henley, J.P., "Analysis Of The Effect Of Chemical Modification On The Activity And Stability Of Enzymes," 7th Symposium On Biotechnology For Fuels And Chemicals, Gatlinburg, TN, May 15-18, 1985.

 

85.         Henley, J.P., Snipes, C.R., and Sadana, A., "Stabilization Of Enzyme Activity By A Series-Type Mechanism. Biomedical Applications," Annual Conference On Engineering In Medicine And Biology, Los Angeles, CA, September 17-19, 1984.

 

86.         Henley, J.P. and Sadana, A., "An Analysis Of Enzyme Stabilization By A Series-Type Mechanism. Influence Of Chemical Modifiers," 6th Symposium On Biotechnology For Fuels And Chemicals, Gatlinburg, TN, May 15-18, 1984.

 

87.         Henley, J.P. and Sadana, A., "Influence Of External Mass Transfer Limitations On Optimum Temperature Operations Policies In Deactivating Fixed-Bed Reactors," National AIChE Meeting, Atlanta, GA, March 11-14, 1984.    

 

88.         Henley, J.P. and Sadana, A., "A Categorization Of Enzyme Deactivations Using A Series-Type Mechanism," VII International Biotechnology Symposium," New Delhi, India, February 19-24, 1984.

 

89.         Henley, J.P. and Sadana, A., "Influence Of Intermediate Activity On Series-Type Enzyme Deactivations. Biomedical Applications," Second Southern Biomedical Engineering Conference, San Antonio, TX, September 26-27, 1983.

 

90.         Henley, J.P. and Sadana, A., "Series-Type Enzyme Deactivation Kinetics. Influence Of Immobilization, Chemical Modifiers, And Aging," VII International Conference On Enzyme Engineering, White Haven, PA, September 25-30, 1983. 

 

91.         Henley, J.P. and Sadana, A., "Modeling Of Series-Type Enzyme Deactivations. Influence Of Precursor (Intermediate) Activity On Inactivation Kinetics," AIChE Summer National Meeting, Denver, CO, August 28-31, 1983.

 

92.         Henley, J.P. and Sadana, A., "Modeling Of Series-Type Enzyme Deactivations. A Simple Probabilistic Approach," AIChE Summer National Meeting, Denver, CO, August 28-31, 1983.

 

93.         Henley, J.P. and Sadana, A., "Influence Of Intermediate Activity On Series-Type Enzyme Deactivation Kinetics," Symposium On Biotechnology For Fuels And Chemicals, Gatlinburg, TN, May 1983.

 

94.         Sadana, A., "On The Influence Of Optimum Temperature Operations Policies On The Intrinsic Order Of Deactivation And Reaction In Fixed-Bed And Batch Reactors," IASTED International Symposium On Applied Simulation And Modeling, ASM 83, San Francisco, CA, May 16-18, 1983.

 

95.         Sadana, A., "Improved Optimum Temperature Operations In Deactivating Fixed-Bed Reactors," 1983 AIChE Spring National Meeting, Houston, TX, March 27-31, 1983.

 

96.         Sadana, A., "Simple Probabilistic Approach To Enzyme Deactivations. Effect Of Enzyme Defects And Aging On Kinetics," Annual AIChE Meeting, Los Angeles, CA, November 14-18, 1982.

 

97.         Sadana, A., "Effect Of Enzyme Defects And Aging On Enzyme Deactivation Kinetics. A Simple Probabilistic Approach," AIChE National Meeting, Anaheim, CA, June 7-10, 1982.

 

98.         Sadana, A., "On A Simple Probabilistic Approach To Disguised Kinetics In Enzyme Deactivation," Fourth Symposium On Biotechnology In Energy Production And Conservation, Gatlinburg, TN, May 11-14, 1982.

 

99.         Sadana, A., "Probability Theory Applied to Enzyme Deactivations,"  AIChE National Meeting, Orlando, FL, February 28-March 3, 1982.

 

100.      Sadana, A., "Intra-Particle Diffusion Effects In Liquid-Phase Hydrocarbon Oxidations," AIChE National Meeting, Orlando, FL, February 28-March 3, 1982.

 

101.      Sadana, A., "An Optimum Temperature Policy In Deactivating Fixed-Bed Reactors," 32nd Annual IIChE Meeting, Indian Institute Of Technology, Bombay, India, December 21-24, 1979.

 

102.      Sadana, A., "On Critical Catalyst Concentration In Liquid-Phase Hydrocarbon Oxidations," 32nd Annual IIChE Meeting, Indian Institute Of Technology, Bombay, India, December 21-24, 1979.

 

103.      Sadana, A., "On An Optimum Temperature Operation Criterion For Deactivating Immobilized Enzyme Fixed-Bed And Batch Reactors," 31st Annual IIChE Meeting, Cochin, India, December 23-26, 1978.

 

104.      Sadana, A., "Intra-Particle Diffusion Effects In Aqueous-Phase Phenol Oxidation," The 4th National Symposium On Catalysis, Indian Institute Of Technology, Bombay, India, December 2-4, 1978.

 

105.      Sadana, A., "An Optimum Temperature Operations Policy For A  Deactivating Moving-Bed Reactor," 4th National Symposium On Catalysis, Indian Institute Of Technology, Bombay, India, December 2-4, 1978.

 

106.      Sadana, A., "Multi-Effect Evaporation And Pyrolyzation Of Waste-Water Residues And Energy Recovery," Conference On "Zero Discharge Of Wastewater Residues," Sponsored By EPA, Mayflower Hotel, Washington, DC, February 1975.

 

107.      Sadana, A. and Katzer, J.R., "Catalytic Oxidation Of Phenol In Aqueous Solution," Fourth Environmental Engineering And Science Conference, Speed Scientific School, University of Louisville, KY, March 4-5, 1974.

 

108.      Ficke, H.H., Katzer, J.R., and Sadana, A., "An Economic Analysis Of Heterogeneously-Catalyzed Aqueous-Phase Oxidation Of Phenol," Annual Industrial Wastes Conference, Purdue University, Lafayette, IN, May 7-9, 1974.

 

109.      Sadana, A. and Katzer, J.R., "Catalytic Oxidation Of Phenol In Aqueous Solution," Catalysis Club Of Philadelphia, PA, March 2-4, 1974.

 

INVITED LECTURES

 

  1. “A Fractal Analysis Of Analyte-Receptor Binding Kinetics In Biosensors,” Department of Physics, University of Memphis, Memphis, October, 2003.

 

  1. “Protein Folding/Misfolding:  Biomedical Implications,” Biological Engineering Department, University of Missouri, Columbia, November 19, 2002. 

 

  1. “An Analysis Of Cell-Ligand, Ligand-Receptor, And Antigen-Antibody Interactions Occurring In Parallel Using Biosensors,” 76th Colloid And Surface Science Symposium, University Of Michigan, Ann Arbor, Michigan, June 23-26, 2002.

 

  1. “A Fractal Analysis Of Analyte-Estrogen Receptor Binding Kinetics On Biosensors: Environmental And Biomedical Applications,” 76th Colloid And Surface Science Symposium, University Of Michigan, Ann Arbor, Michigan, June 23-26, 2002.

 

  1. “A Kinetic Study Of Analyte-Receptor Binding And Dissociation For Surface Plasmon Resonance Biosensor Applications,” IEEE Sensors 2002, Orlando, Florida, June 12-14, 2002. 

 

  1. “A Fractal Analysis Of Electrocardiograms: Stratification of Hereditary Risk For Hypertrophic Cardiomyopathy,” Civil Engineering Department, September 6, 2001.

 

  1. “A Fractal Analysis of Cellular Analyte-Receptor Binding Kinetics Using Biosensors,” Chemical Engineering Department, University of Missouri, February 12, 2001.

 

  1. “A Fractal Analysis Of Electrocardiograms To Risk-Stratify Family Members For Hypertrophic Cardiomyopathy,” Department of Biological Engineering, University Of Missouri, February 13, 2001.

 

  1. "A Fractal Analysis Of Electrocardiograms," Electrical Engineering Department, University of Mississippi, September 1999.

 

  1. "Influence Of Diffusion To Fractal Surfaces On The Binding Kinetics For Antibody-Antigen, Analyte-Receptor, And Analyte-Receptorless (Protein) Systems," Mid-Atlantic  Regional Meeting, American Chemical Society, Theme: Drug Discovery, Pace University, Pleasantville, NY, May 27-30, 1997.

 

  1. "A Fractal Analysis Of The Influence Of Non-Specific Binding On Antigen-Antibody Binding Kinetics For Biosensor Applications," Mid-Atlantic Regional Meeting, American Chemical Society, Theme: Drug Discovery, Pace University, Pleasantville, NY, May 27-30, 1997.

 

  1. "Antigen-Antibody Binding Kinetics For Biosensor  Applications: A Fractal And Engineering Analysis," National Center for Physical Acoustics, University of Mississippi, March 4, 1997.

 

  1. "Protein Adsorption on Biomaterials," Chemistry Department, University of Mississippi, March 29, 1994.

 

  1. "Effect Of Chemical Modification On Enzyme Activities And Stabilities," Symposium On Biocatalyst Design For Stability And Specificity, 202 ACS Meeting, New York, September 1991.

 

  1. "Basics Of Enzyme Deactivation," Memphis State University, Memphis, TN, March 1991.

 

  1. "Influence Of Chemical Modification On Enzyme Activity And Stability. A Categorization," Experimental Station, E.I. duPont and Company, Wilmington, DE, August 1988.

 

  1. "Effect Of Chemical Modification On Enzyme Activities And Stabilities," Vanderbilt University, Nashville, TN, November 1988.

 

  1. "Effect Of Chemical Modification On Enzyme Activities And Stabilities," Eidgenossiche Technische Hochschule, Zurich, Switzerland, May 1985.

 

  1. “Series-Type Enzyme Deactivations. Influence Of Intermediate Activity On Deactivation Kinetics And Of Chemical Modifiers On Enzyme Stabilization," Eidgenossiche Technische Hochschule, Zurich, Switzerland, May 1984.